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Young adulthood obesity and risk of acute coronary syndromes, stable angina pectoris, and congestive heart failure: A 36-year cohort study

机译:一项为期36年的队列研究显示,年轻成人肥胖症和急性冠状动脉综合征,稳定型心绞痛和充血性心力衰竭的风险

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Purpose: To examine the association between young adulthood obesity and long-term risk of ischemic heart disease (IHD) and nonischemic congestive heart failure (CHF). Methods: We conducted a population-based cohort study of 12,850 male conscripts whose fitness for military service was examined by Draft Boards in Northern Denmark. Outcomes were obtained from the Danish National Patient Registry, covering all Danish hospitals since 1977. Follow-up began on the 22nd birthday of each subject and continued until occurrence of an outcome, emigration, death, or on December 31, 2012, whichever came first. We used Cox regression to compute hazard ratios (HRs). Results: The 36-year risk was 7.3% for IHD and 0.8% for CHF without pre-existing IHD among men of normal weight and 11.1% and 4.0% among obese men, respectively. Comparing obese men with men of normal weight, the adjusted HR was 1.63 (95% confidence interval [CI], 0.98-2.73) for IHD overall, 2.86 (95% CI, 1.56-5.25) for myocardial infarction, 5.52 (95% CI, 2.38-12.82) for unstable angina, 1.29 (95% CI, 0.69-2.41) for stable angina, and 6.68 (95% CI, 2.85-15.66) for CHF without pre-existing IHD. Conclusions: Young adulthood obesity was an important risk factor for IHD but also for CHF without pre-existing IHD.
机译:目的:探讨成年肥胖与长期缺血性心脏病(IHD)和非缺血性充血性心力衰竭(CHF)之间的关系。方法:我们进行了一项基于人群的队列研究,研究了12850名男性应征入伍者,其服役状况由北丹麦的草案委员会审查。从1977年以来覆盖丹麦所有医院的丹麦国家病人登记处获得结果。随访始于每个受试者的22岁生日,一直持续到发生结局,移民,死亡或2012年12月31日,以先到者为准。 。我们使用Cox回归来计算危险比(HRs)。结果:正常体重的男性中,不存在IHD的IHD的36年风险分别为7.3%和CHF的0.8%,肥胖男性中分别为11.1%和4.0%。将肥胖男性与体重正常的男性进行比较,整体IHD的校正后HR为1.63(95%置信区间[CI],0.98-2.73),心肌梗塞的校正后HR为2.86(95%CI,1.56-5.25),5.52(95%CI) ,对于不稳定型心绞痛为2.38-12.82),对于稳定型心绞痛为1.29(95%CI,0.69-2.41),对于没有预先存在IHD的CHF,则为6.68(95%CI,2.85-15.66)。结论:成年后的年轻肥胖是IHD的重要危险因素,也是既往没有IHD的CHF的重要危险因素。

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