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首页> 外文期刊>Annals of epidemiology >A prospective study of green tea consumption and oral cancer incidence in Japan.
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A prospective study of green tea consumption and oral cancer incidence in Japan.

机译:日本绿茶消费与口腔癌发病率的前瞻性研究。

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PURPOSE: To examine the relation of green tea consumption with oral carcinogenesis, we prospectively analyzed data from a nationwide large-scale cohort study in Japan. METHODS: A total of 20,550 men and 29,671 women aged 40-79 years, without any history of oral and pharyngeal cancer at baseline survey, were included in the present study. During a mean follow-up period of 10.3 years, 37 oral cancer cases were identified. The Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) for oral cancer according to green tea consumption by sex, while adjusting for age, smoking, alcohol drinking, and other dietary factors. RESULTS: For women, the HRs of oral cancer for green tea consumption of 1-2, 3-4, and 5 or more cups per day were 0.51 (95% CI: 0.10-2.68), 0.60 (95% CI: 0.17-2.10), and 0.31 (95% CI: 0.09-1.07), respectively, compared with those who drank less than one cup per day (p for trend, 0.08). For men, no such trends were observed. CONCLUSIONS: Our findings did not suggest a prominent inverse association of green tea consumption with oral cancer, although there was a tendency for a reduced risk in women.
机译:目的:为检验绿茶摄入量与口腔癌发生的关系,我们前瞻性地分析了来自日本全国范围内大规模队列研究的数据。方法:本研究共纳入20,550名男性和29,671名女性,年龄在40-79岁之间,在基线调查中没有任何口腔癌和咽癌的病史。在平均10.3年的随访期内,发现了37例口腔癌病例。使用Cox比例风险模型根据性别对绿茶的摄入量估算口腔癌的风险比(HR)和95%置信区间(95%CI),同时根据年龄,吸烟,饮酒和其他饮食因素进行调整。结果:对于女性而言,每天饮用1-2、3-4和5杯或更多杯绿茶的口腔癌的HRs为0.51(95%CI:0.10-2.68),0.60(95%CI:0.17-与每天喝少于一杯的人相比,分别为2.10)和0.31(95%CI:0.09-1.07)(趋势p为0.08)。对于男性,没有观察到这种趋势。结论:尽管有降低女性患病风险的趋势,但我们的研究结果并未表明食用绿茶与口腔癌之间存在显着的负相关关系。

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