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首页> 外文期刊>Annals of epidemiology >Diet during pregnancy and risk of preeclampsia or gestational hypertension.
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Diet during pregnancy and risk of preeclampsia or gestational hypertension.

机译：怀孕期间饮食和先兆子痫或妊娠高血压的风险。

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PURPOSE: We sought to examine associations of first-trimester intake of calcium, n-3 and n-6 fatty acids, trans fatty acids, magnesium, folate, and vitamins C, D, and E with preeclampsia (PE) and gestational hypertension (GH). METHODS: We studied associations of diet with PE or GH among 1718 women in the prospective cohort study Project Viva, using logistic regression and adjusting for maternal age, prepregnancy body mass index, first trimester systolic blood pressure, race/ethnicity, education, and parity. We assessed first-trimester diet using a validated semiquantitative food frequency questionnaire. RESULTS: A total of 59 (3%) women developed PE, and 119 developed (7%) GH. We found a somewhat-lower risk of PE associated with higher intake of the elongated n-3 fatty acids docosahexaenoic and eicosapentaenoic acids (odds ratio [OR] 0.84, 95% confidence interval [95% CI]: 0.69-1.03 per 100 mg/day), fish (OR 0.91, 95% CI 0.75-1.09 per serving/day), and the ratio of docosahexaenoic + eicosapentaenoic toarachadonic acid (OR 0.82, 95% CI 0.66-1.01). We did not observe a lower risk of GH or PE with a greater intake of calcium; vitamin C, D, or E; milk; magnesium; folate; or with lower intake of n-6 or trans fatty acids. CONCLUSIONS: Our results support a potential benefit for elongated n-3 fatty acids in preventing preeclampsia.
机译：目的：我们试图检查孕早期摄入钙，n-3和n-6脂肪酸，反式脂肪酸，镁，叶酸以及维生素C，D和E与先兆子痫（PE）和妊娠高血压的相关性（ GH）。方法：我们在前瞻性队列研究项目Viva中研究了1718名女性饮食与PE或GH的关联，使用逻辑回归分析并调整了产妇年龄，孕前体重指数，孕早期收缩压，种族/民族，教育程度和均等程度。我们使用经过验证的半定量食物频率问卷评估了孕早期饮食。结果：共有59名（3％）妇女患上了PE，119名妇女患了GH。我们发现，与摄入更多的长形n-3脂肪酸二十二碳六烯酸和二十碳五烯酸有关的PE风险较低（几率[OR] 0.84，95％置信区间[95％CI]：0.69-1.03每100 mg /天），鱼（OR 0.91、95％CI 0.75-1.09 /份/天）和二十二碳六烯酸+二十碳五烯酸二十碳五烯酸的比例（OR 0.82,95％CI 0.66-1.01）。我们并没有观察到钙摄入量增加会降低GH或PE的风险。维生素C，D或E;牛奶;镁;叶酸或摄入较少的n-6或反式脂肪酸。结论：我们的结果支持延长n-3脂肪酸在预防先兆子痫中的潜在益处。

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