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首页> 外文期刊>Annals of epidemiology >Lifestyle, anthropometric, and obesity-related physiologic determinants of insulin-like growth factor-1 in the Third National Health and Nutrition Examination Survey (1988-1994).
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Lifestyle, anthropometric, and obesity-related physiologic determinants of insulin-like growth factor-1 in the Third National Health and Nutrition Examination Survey (1988-1994).

机译：胰岛素样生长因子-1的生活方式，人体测量学和与肥胖相关的生理决定因素在第三次全国健康与营养调查中（1988-1994）。

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PURPOSE: Epidemiologic studies suggest that insulin-like growth factor-1 (IGF-1) is associated with obesity and, more recently, cancer. This study investigates multiple lifestyle, physiologic, and anthropometric determinants of circulating IGF-1 concentrations. METHODS: Nationally representative data were used from the cross-sectional Third National Health and Nutrition Examination (NHANES III, 1988-1994) survey, which measured IGF-1 concentrations in blood, from a subsample of participants who were examined in the morning. After exclusion of persons with missing data, 6,058 men and women 20 years of age or older were included in the study. RESULTS: The mean IGF-1 concentrations were 260 ng/mL in the entire population and were higher among men as compared with women (278.8 vs. 241.3 ng/mL; p<0.0001). IGF-1 decreased with increasing age (p<0.0001), body mass index (p<0.0001), and waist circumference (p<0.0001). Individuals with metabolic syndrome had lower IGF-1 concentrations after adjustment for covariates (p=0.0008). IGF-1 was inversely associated with increasing number of metabolic syndrome abnormalities (p=0.0008). All associations were stronger among women compared with men except across concentrations of glucose. IGF-1 concentrations did not vary by any other lifestyle or physiologic factors. CONCLUSIONS: Age, adiposity, hyperglycemia, and metabolic syndrome influenced circulating IGF-1 concentrations. Diet and physical activity had no impact on IGF-1 in this nationally representative population.
机译：目的：流行病学研究表明，胰岛素样生长因子-1（IGF-1）与肥胖症有关，最近与癌症有关。这项研究调查了多种IGF-1浓度的生活方式，生理和人体测量学决定因素。方法：使用全国代表性的数据来​​自于第三次全国健康与营养检查（NHANES III，1988-1994）横断面调查，该调查测量了早晨检查的参与者的一个子样本中的血液中IGF-1浓度。在排除缺少数据的人之后，研究中包括了2058岁或以上的6,058名男性和女性。结果：整个人群中平均IGF-1浓度为260 ng / mL，男性高于女性（278.8 vs. 241.3 ng / mL; p <0.0001）。 IGF-1随年龄增加（p <0.0001），体重指数（p <0.0001）和腰围（p <0.0001）而降低。调整协变量后，代谢综合征患者的IGF-1浓度较低（p = 0.0008）。 IGF-1与代谢综合征异常数量的增加呈负相关（p = 0.0008）。与男性相比，女性之间的所有关联都更强，只是葡萄糖浓度不同。 IGF-1浓度不受任何其他生活方式或生理因素的影响。结论：年龄，肥胖，高血糖和代谢综合征影响循环中IGF-1的浓度。饮食和体育锻炼对这一全国代表性人群的IGF-1没有影响。

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