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Hypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: A collaborative study

机译：一项合作研究表明，高血压和低HDL胆固醇与整个年龄段的肾功能下降有关

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Purpose: To determine if the associations among established risk factors and reduced kidney function vary by age. Methods: We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort. Results: Hypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertension was associated with a 2.3 (95% confidence interval [CI], 0.1, 4.4), 5.1 (95% CI, 4.1, 6.1), and 6.9 (95% CI, 3.0, 10.4) mL/min/1.73 m2 lower eGFR in participants 40 to 59, 60 to 79, and at least 80 years, respectively (P for interaction .001). The association of low HDL cholesterol with reduced kidney function was also greater in the older age groups: 4.9 (95% CI, 3.5, 6.3), 7.1 (95% CI, 6.0, 8.3), 8.9 (95% CI, 5.4, 11.9) mL/min/1.73 m2 (P for interaction .001). Smoking and obesity were associated with reduced kidney function in participants under 80 years. All estimates of the potential population impact of the risk factors were modest. Conclusions: Hypertension, obesity, smoking, and low HDL cholesterol are modestly associated with reduced kidney function in nondiabetics. The associations of hypertension and HDL cholesterol with reduced kidney function seem to be stronger in older adults. ? 2013 Elsevier Inc.
机译：目的：确定既定危险因素与肾功能降低之间的关联是否随年龄变化。方法：我们在4个研究中收集了14788名40至100岁的非糖尿病患者的横断面数据：心血管健康研究，健康，衰老和身体成分研究，动脉粥样硬化的多民族研究以及肾脏和血管末期疾病的预防队列。结果：高血压和低高密度脂蛋白（HDL）胆固醇与年龄谱中基于胱抑素C的估计肾小球滤过率（eGFR）降低有关。在调整后的分析中，高血压与2.3（95％置信区间[CI]，0.1、4.4），5.1（95％CI，4.1、6.1）和6.9（95％CI，3.0、10.4）mL / min /相关。 40至59岁，60至79岁和至少80岁的参与者的eGFR降低了1.73平方米（交互作用P <0.001）。低HDL胆固醇与肾功能降低的相关性在老年人群中也更大：4.9（95％CI，3.5，6.3），7.1（95％CI，6.0，8.3），8.9（95％CI，5.4，11.9）毫升/分钟/1.73平方米（相互作用P <0.001）。吸烟和肥胖与80岁以下参与者的肾功能下降有关。对危险因素对人口的潜在影响的所有估计均不高。结论：高血压，肥胖，吸烟和低HDL胆固醇与非糖尿病患者的肾功能下降有中等程度的相关性。高血压和高密度脂蛋白胆固醇与肾功能降低的关联在老年人中似乎更强。 ？ 2013爱思唯尔公司

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