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A systematic review of the application of spatial analysis in pharmacoepidemiologic research

机译：系统分析空间分析在药物流行病学研究中的应用

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摘要

Purpose: Although current reviews of the use of spatial analysis in general epidemiologic research illustrate an important and well-established role in exploring and predicting health, its application has not been reviewed in the subspecialty field of pharmacoepidemiology. Methods: We systematically reviewed the scientific literature to assess to what extent spatial analysis has been applied in pharmacoepidemiologic research and explored its potential added value. Results: A systematic search in PubMed and Embase/MEDLINE yielded 823 potentially relevant articles; 45 articles met our criteria for review. The studies were reviewed on study objective, applied spatial methods and units of analysis, and author-reported added value of the geographic approach used. Of the 45 included studies, 34 (76%) reported a geographic research objective. Comparative spatial methods were most often used (n= 25; 56%). Eleven studies used spatial statistics (32%); cluster analysis (n= 5) and aggregate data analysis (n= 4) being most common. Mapping was done in 15 studies (33%). The most common added value reported was to aid the planning of health policies and interventions (n= 24; 53%). A minority of pharmacoepidemiologic studies used a geographic approach and the applied methods were less advanced compared with the broader field of epidemiology. Conclusions: Further advancements are needed to incorporate currently available spatial techniques to impact health care planning.
机译：目的：尽管目前对流行病学研究中使用空间分析的评论表明了在探索和预测健康方面的重要且已确立的作用，但尚未在药物流行病学的专业领域中对它的应用进行过评论。方法：我们系统地回顾了科学文献，以评估空间分析在药物流行病学研究中的应用程度，并探讨了其潜在的附加值。结果：在PubMed和Embase / MEDLINE中进行的系统搜索产生了823篇可能相关的文章; 45篇文章符合我们的审查标准。对研究进行了研究，包括研究目的，应用的空间方法和分析单位，以及作者报告的所用地理方法的附加值。在45项纳入研究中，有34项（76％）报告了地理研究目标。比较空间方法是最常用的方法（n = 25; 56％）。十一项研究使用了空间统计（32％）;聚类分析（n = 5）和聚合数据分析（n = 4）最常见。进行了15项研究（33％）的作图。报告的最常见的增加值是帮助制定卫生政策和干预措施（n = 24; 53％）。少数药物流行病学研究使用地理方法，与更广泛的流行病学领域相比，应用的方法不那么先进。结论：需要进一步的进展以结合当前可用的空间技术来影响卫生保健计划。

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