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首页> 外文期刊>Annals of epidemiology >Differences between Hispanic and non-Hispanic white women with breast cancer for clinical characteristics and their correlates
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Differences between Hispanic and non-Hispanic white women with breast cancer for clinical characteristics and their correlates

机译：西班牙裔和非西班牙裔白人女性乳腺癌的临床特征差异及其相关性

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Purpose: Body size and ethnicity may influence breast cancer tumor characteristics at diagnosis. We compared Hispanic and non-Hispanic white (NHW) cases for stage of disease, estrogen receptor (ER) status, tumor size, and lymph node status, and the associations of these with body size in the 4-Corners Breast Cancer Study. Methods: One thousand five hundred twenty-seven NHW and 798 Hispanic primary incident breast cancer cases diagnosed between October 1999 and May 2004 were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multiple logistic regression. Results: Hispanic women were more likely to have larger (>1 cm) ER- tumors and more than four positive lymph nodes (P < .003). Lymph node status was not associated with body size. However, among NHW women, obesity (body mass index >30) and increased waist circumference (>38.5 inches) were significantly positively associated with ER- tumor status (OR, 1.87; 95% CI, 1.24-2.81 and OR, 2.59; 95% CI, 1.58-4.22, respectively). In contrast, among Hispanic women, obesity and waist circumference had inverse associations with ER- tumor status (OR, 0.49; 95% CI, 0.29-0.84 and OR, 0.56; 95% CI, 0.30-1.05, respectively). Conclusions: Hispanic ethnicity may modify the association of body size and composition with ER- breast cancer. This finding could have relevance to clinical treatment and prognosis.
机译：目的：身体大小和种族可能会影响诊断时的乳腺癌肿瘤特征。在4角乳腺癌研究中，我们比较了西班牙裔和非西班牙裔白人（NHW）的疾病阶段，雌激素受体（ER）状态，肿瘤大小和淋巴结状态，以及这些与体重的相关性。方法：纳入1999年10月至2004年5月期间诊断的157例NHW和798例西班牙裔原发性乳腺癌病例。通过多元逻辑回归计算出赔率（OR）和95％置信区间（CI）。结果：西班牙裔女性更有可能患有更大（> 1 cm）的ER-肿瘤和超过四个阳性淋巴结（P <.003）。淋巴结状态与体重无关。然而，在NHW妇女中，肥胖（体重指数> 30）和腰围增加（> 38.5英寸）与ER肿瘤状态显着正相关（OR为1.87; 95％CI为1.24-2.81，OR为2.59; 95） ％CI，分别为1.58-4.22）。相反，在西班牙裔女性中，肥胖和腰围与ER肿瘤状态呈负相关（OR，分别为0.49; 95％CI，0.29-0.84和OR，0.56; 95％CI，0.30-1.05）。结论：西班牙裔种族可能会改变体型和成分与ER-乳腺癌的关系。这一发现可能与临床治疗和预后有关。

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