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首页> 外文期刊>Annals of epidemiology >Anthropometric measurements, physical activity, and the risk of symptomatic gallstone disease in Chinese women.
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Anthropometric measurements, physical activity, and the risk of symptomatic gallstone disease in Chinese women.

机译：人体测量学，体育锻炼和中国女性有症状胆结石疾病的风险。

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PURPOSE: Gallstone disease is more common among overweight individuals, particularly in women. We conducted a cross-sectional case-control study of Chinese women nested in the Shanghai Women's Health Study (SWHS) to evaluate the association of gallstone disease with body mass index (BMI), waist to hip ratio (WHR), and physical activity (PA). METHODS: The study included 8,485 women with self-reported, physician-diagnosed, prevalent gallstone disease and 16,970 frequency-matched controls by birth year and age at gallstone diagnosis (4-year intervals). Information on height, weight history, waist and hip circumferences, physical activities, and other exposures was obtained by in-person interview. RESULTS: : Usual BMI (p trend < 0.001) and WHR (p trend < 0.001) were both related to a high prevalence of gallstone disease, and a significant interaction between BMI and WHR on gallstone risk was found (odds ratio [OR] = 3.82, 95%CI [95% confidence interval] 2.47-5.23 for those with both highest BMI and WHR relative to those with lowest BMI and WHR, p interaction = 0.03). Gallstone risk was positively associated with cumulative occupational sitting time (p trend = 0.01) and inversely associated with occupational cumulative energy expenditure (p trend = 0.03) as well as with household PA (p trend = 0.02). CONCLUSIONS: Our findings further support that overall and central excessive adiposity is an independent risk factor for gallstones in women. In addition, regardless of adiposity level, being physically active may ameliorate the risk of this disease.
机译：目的：胆结石病在超重人群中更为普遍，特别是在女性中。我们在《上海妇女健康研究》（SWHS）中对中国妇女进行了横断面病例对照研究，以评估胆结石疾病与体重指数（BMI），腰臀比（WHR）和身体活动（ PA）。方法：该研究纳入了8485名患有自我报告，经医生诊断为流行性胆结石疾病的妇女，以及在胆结石诊断时（每隔4年）按出生年份和年龄划分的16970例频率匹配的对照。通过面试获得有关身高，体重史，腰围和臀围，身体活动以及其他暴露情况的信息。结果：：通常的BMI（p趋势<0.001）和WHR（p趋势<0.001）均与胆结石患病率高相关，并且发现BMI和WHR之间在胆结石风险方面存在显着相互作用（比值[OR] = BMI和WHR最高的人相对于BMI和WHR最低的人为3.82，95％CI [95％置信区间] 2.47-5.23，p相互作用= 0.03）。胆结石风险与职业累积就座时间呈正相关（p趋势= 0.01），与职业累积能量消耗（p趋势= 0.03）以及家庭PA呈负相关（p趋势= 0.02）。结论：我们的研究结果进一步支持总体和中枢性肥胖是女性胆结石的独立危险因素。此外，无论肥胖水平如何，进行体育锻炼都可以减轻这种疾病的风险。

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