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首页> 外文期刊>Annals of epidemiology >Fetal growth among infants with congenital heart defects by maternal race/ethnicity.
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Fetal growth among infants with congenital heart defects by maternal race/ethnicity.

机译：先天性心脏缺陷婴儿通过母体种族/民族的胎儿生长。

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PURPOSE: Congenital heart defects (CHDs) are the most prevalent birth defects. Infants with CHDs more often are small-for-gestational age (SGA) than infants without CHD; however, little is known about racial/ethnic variations in prevalence of SGA or large-for-gestational age (LGA) for infants born with CHDs. This study determined the risk of SGA and LGA for non-Hispanic (NH)-black and Hispanic infants with CHDs. METHODS: Data from the Florida Birth Defects Registry were used in a retrospective cohort study of 10,027 live-born infants to resident NH-White, NH-Black, and Hispanic women ages 15-49 years from January 1, 1998, to December 31, 2003, and diagnosed with 11 CHDs. Defect-specific odds ratios and 95% confidence intervals were computed for risk of SGA and LGA by race/ethnicity and adjusted for covariates using multinomial logistic regression. RESULTS: After adjusting for covariates, we found there were no statistically significant racial/ethnic differences in risk of SGA. However, NH-Blacks with ventricular septal defect had increased risk of LGA and NH-Blacks with tetralogy of Fallot had decreased risk of LGA compared to NH-Whites. CONCLUSIONS: Very few racial/ethnic differences in fetal growth are present among infants with CHD. Further elucidation of the factors involved in fetal growth and the impact of CHD itself on fetal development is needed.
机译：目的：先天性心脏缺陷（CHD）是最普遍的出生缺陷。与没有冠心病的婴儿相比，冠心病的婴儿更容易达到胎龄。然而，对于患有冠心病的婴儿，其SGA患病率或大胎龄（LGA）的种族/种族差异知之甚少。这项研究确定了非西班牙裔（NH）黑人和西班牙裔冠心病婴儿的SGA和LGA风险。方法：从1998年1月1日至12月31日，对年龄在15-49岁的NH-White，NH-Black和西班牙裔居民的10027例活产婴儿进行回顾性队列研究，采用了佛罗里达出生缺陷登记处的数据， 2003年，被诊断出患有11种冠心病。通过种族/民族来计算SGA和LGA风险的缺陷特异性比值比和95％置信区间，并使用多项逻辑回归来调整协变量。结果：校正协变量后，我们发现SGA的风险在统计学上没有种族/种族差异。然而，与NH-Whites相比，具有室间隔缺损的NH-Blacks发生LGA的风险增加，而具有Fallot四联症的NH-Blacks发生LGA的风险降低。结论：冠心病婴儿在胎儿生长方面几乎没有种族/种族差异。需要进一步阐明涉及胎儿生长的因素以及冠心病本身对胎儿发育的影响。

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