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首页> 外文期刊>Annals of epidemiology >Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults.
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Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults.

机译：在一项基于人群的研究中，对9733名老年人进行了饮酒，血清γ-谷氨酰转移酶和幽门螺杆菌感染的研究。

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PURPOSE: Moderate alcohol consumption has been suggested to facilitate the elimination of Helicobacter pylori infection as the result of its antibacterial effect. We aimed to assess the associations of current and lifetime alcohol consumption as well as serum gamma-glutamyltransferase (GGT), an established biomarker of alcohol consumption, with H. pylori infection in a large population-based study. METHODS: In the baseline examination of the ESTHER study, serological measurements of antibodies against H. pylori and GGT measurements were taken in 9733 subjects ages 50 to 74 years. Information on lifestyle factors and medical history were obtained by self-administered standardized questionnaire. RESULTS: A significant inverse association, in dose-response manner, was observed between both current and lifetime alcohol consumption and H. pylori seropositivity. The estimates based on lifetime consumption were more pronounced than the results for current consumption, and such inverse associations were found both for men and women. Stronger relations were observed for those who only drank wine or mixed drinkers compare with those who only drank beer. Furthermore, there was a significant inverse dose-response relationship between serum GGT levels and H. pylori seropositivity, which was selectively observed among alcohol drinkers. CONCLUSIONS: In conclusion, our results support the hypothesis that moderate alcohol consumption may facilitate elimination of H. pylori.
机译：目的：由于其抗菌作用，已建议适度饮酒以消除幽门螺杆菌感染。我们的目的是在大量的基于人群的研究中评估当前和终生的酒精消耗以及血清γ-谷氨酰转移酶（GGT）（一种建立的酒精消耗生物标志物）与幽门螺杆菌感染之间的关联。方法：在ESTHER研究的基线检查中，对9733名年龄在50至74岁的受试者进行了针对幽门螺杆菌的抗体的血清学检测和GGT检测。通过自我管理的标准化问卷获得有关生活方式因素和病史的信息。结果：当前和终生饮酒量与幽门螺杆菌血清阳性之间均存在剂量-反应的显着负相关。基于终生消费量的估算比当前消费量的估算更为显着，男女之间都存在这种反相关。与仅喝酒或喝酒的人相比，那些只喝葡萄酒或混合酒的人之间的关系更紧密。此外，在饮酒者中有选择地观察到血清GGT水平与幽门螺杆菌血清阳性之间存在显着的剂量-反比关系。结论：总之，我们的研究结果支持以下假设：适度饮酒可能有助于消除幽门螺杆菌。

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