Targeting reservoirs of HIV replication in lymphoid follicles with cellular therapies to cure HIV

Pamela J. Skinner

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Targeting reservoirs of HIV replication in lymphoid follicles with cellular therapies to cure HIV

机译：靶向用细胞疗法治愈HIV的淋巴卵泡中HIV复制的储层

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There is a need to create improved treatments for HIV infection. Growing evidence indicates that HIV treatment strategies must target and reduce viral replication in lymphoid follicles where HIV replication is most concentrated. In this mini-review, three cell therapy approaches are described: CAR-T and CAR-NK cells, adoptive transfer of autologous HIV-specific T cells, and HIV-resistant cells. The potential for these innovative strategies to reduce viral replication in follicles and the potential of combining cell therapies with other treatment strategies to achieve a complete eradication of HIV is discussed.

机译：有必要为HIV感染创造改进的治疗方法。越来越多的证据表明，艾滋病毒治疗策略必须靶向并减少最集中艾滋病毒复制的淋巴卵泡中的病毒复制。在这一小评论中，描述了三种细胞疗法：CAR-T和CAR-NK细胞，自体HIV特异性T细胞的产物转移以及耐HIV的细胞。讨论了这些创新策略减少卵泡中病毒复制的潜力，以及将细胞疗法与其他治疗策略相结合以实现HIV的完全消除的潜力。

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《Advances in cell and gene therapy.》 |2019年第1期|e27-e27|共1页
作者
Pamela J. Skinner;
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作者单位

Microbiology Research Facility, Veterinary and Biomedical Sciences Department, University of;

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原文格式 PDF
正文语种英语
中图分类
关键词
Cell Therapy; lymphatic nodule; FolliclesHIVVirus ReplicationHIV Infectionsex vivo-expanded HER2-specific T cellschimeric antigen receptor T-cell;

机译：细胞疗法;淋巴结;卵泡病毒复制HIV感染SEPENCEX体内HER2特异性T细胞嵌合抗原受体T细胞T细胞T细胞T细胞;

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Targeting reservoirs of HIV replication in lymphoid follicles with cellular therapies to cure HIV

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