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Advances in the treatment of chronic graft-versus-host disease

机译:治疗慢性移植抗宿主病的进展

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摘要

Chronic Graft Versus Host Disease (cGVHD) occurs in over 50-70% of patients undergoing hematopoietic stem-cell transplantation (HSCT) and is the leading cause of late non-relapse mortality. cGVHD typically has insidious multi-organ involvement and has been associated with a worse quality of life, functional status, and increased risk of subsequent comorbidities. The last several years have seen advances in the understanding of the disease, which provided a framework for the design of transla-tional and clinical studies with newer agents currently at different phases which that may hopefully change the course of the disease. This review provides an overview of more commonly used and newer second line options for the management of cGVHD.
机译:慢性移植与宿主疾病(CGVHD)发生在超过50-70%的接受造血干细胞移植(HSCT)的患者中,是晚期非释放死亡率的主要原因。 CGVHD通常具有阴险的多器官参与,并且与较差的生活质量,功能状态以及随后合并症的风险增加有关。 在过去的几年中,人们对疾病的理解有所进步,该疾病为设计的框架和临床研究提供了一个框架,目前在不同阶段的新药物,这可能会改变疾病的进程。 这篇评论概述了CGVHD管理的更常用和更新的第二行选项。

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