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首页> 外文期刊>Annals of epidemiology >Hypercholesterolemia and coronary heart disease in the elderly: a meta-analysis.
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Hypercholesterolemia and coronary heart disease in the elderly: a meta-analysis.

机译：高胆固醇血症和老年人冠心病：一项荟萃分析。

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摘要

PURPOSE: To determine whether hypercholesterolemia is an independent risk factor for CHD morbidity and mortality in persons aged 65 years and above, and to quantify the magnitude of the association, if any, using data from follow-up studies. METHODS: A MEDLINE search of all published studies that evaluated the association between high cholesterol levels and CHD in persons aged 65 years and above, and the relevant articles referenced in these studies, were used as sources of selected articles. RESULTS: In men aged 65 years and above who were followed from middle age, the RR for CHD incidence associated with 1.0 mmol/L increase in total cholesterol was 1.28 (CI: 1.17-1.39). The RR for CHD mortality associated with a similar increase in total cholesterol was 1.22 (CI: 1.18-1.27). In elderly men followed from age 65 and above, the RR was 1.24 (CI: 1.1-1.37) for CHD incidence, and 1.22(CI: 1.15-1.28) for CHD mortality. In elderly women followed after age 65, the association between total cholesterol and CHDmortality was not significant. For men aged 80 years and above at entry, total cholesterol showed an inverse relationship with all-cause mortality. CONCLUSION: Serum total cholesterol shows a positive association with CHD morbidity and mortality in men aged 65 years and above. This may, however, not hold true for persons aged 80 years and above.
机译：目的：确定高胆固醇血症是否是65岁及65岁以上人群冠心病发病率和死亡率的独立危险因素，并使用随访研究的数据量化这种关联的程度（如果有）。方法：对所有发表的研究进行了MEDLINE搜索，这些研究评估了65岁及65岁以上人群中高胆固醇水平与冠心病之间的相关性，并将这些研究中引用的相关文章用作所选文章的来源。结果：从中年开始随访的65岁及以上男性中，CHD发生率与总胆固醇增加1.0 mmol / L相关的RR为1.28（CI：1.17-1.39）。与总胆固醇类似升高相关的冠心病死亡率的RR为1.22（CI：1.18-1.27）。在65岁及以上的老年男性中，冠心病的RR为1.24（CI：1.1-1.37），冠心病的死亡率为1.22（CI：1.15-1.28）。在65岁以后随访的老年妇女中，总胆固醇与冠心病死亡率之间的相关性不显着。对于进入年龄80岁及以上的男性，总胆固醇与全因死亡率呈反比关系。结论：65岁及以上男性血清总胆固醇与冠心病发病率和死亡率呈正相关。但是，这可能不适用于80岁以上的人。

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