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首页> 外文期刊>Annals of epidemiology >Serological evidence of Cryptosporidium infections in a Russian city and evaluation of risk factors for infections.
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Serological evidence of Cryptosporidium infections in a Russian city and evaluation of risk factors for infections.

机译:俄罗斯城市隐孢子虫感染的血清学证据和感染危险因素的评估。

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PURPOSE: Assess the relative frequency of Cryptosporidium infections and risk factors for infection in Cherepovets, Russia. METHODS: In June 1999, data on demographic, socioeconomic, hygienic characteristics, and recent gastrointestinal illness were collected on 50 community-recruited adults and 50 blood donors. The community group then maintained daily diaries of exposures and gastrointestinal symptoms for 5 months. Sera samples at the inception and conclusion of the study were tested for antibody responses to the 15/17 kDa and 27 kDa Cryptosporidium antigens using mini-immunoblots. RESULTS: At the inception, 68% and 88% of study participants had detectable serological responses to 15/17 kDa and 27 kDa antigens. Older age was associated with stronger antibody responses to both antigens. Attendance at swimming pools was associated with stronger responses to both antigens in predominantly male blood donors. Over the follow-up period, drinking non-boiled water from shallow draw-wells was associated with an increase in serological response to the 27 kDa antigen. Self-reported gastrointestinal illness was not associated with an increase in serological response. CONCLUSIONS: The prevalence of positive serological responses in Cherepovets was higher than in most prior Cryptosporidium serosurveys in non-outbreak communities. Drinking water is an important pathway for infection.
机译:目的:评估俄罗斯切列波韦茨人隐孢子虫感染的相对频率和感染危险因素。方法:1999年6月,收集了50名社区招募的成年人和50名献血者的人口统计学,社会经济,卫生特征和最近的胃肠道疾病的数据。然后,社区小组保持每日接触日记和胃肠道症状日记,为期5个月。使用微型免疫印迹测试了研究开始和结论时的血清样品对15/17 kDa和27 kDa隐孢子虫抗原的抗体反应。结果:在开始时,有68%和88%的研究参与者对15/17 kDa和27 kDa抗原具有可检测的血清学反应。年龄越大,对两种抗原的抗体反应越强。在主要是男性献血者中,参加游泳池与对两种抗原的较强反应有关。在随访期间,从浅抽水井饮用未煮沸的水与对27 kDa抗原的血清学应答增加有关。自我报告的胃肠道疾病与血清学反应的增加无关。结论:在非暴发人群中,Cherepovets中阳性血清反应的发生率高于大多数以前的隐孢子虫血清调查。饮用水是感染的重要途径。

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