Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

Niculescu Duvaz-I; Friedlos F; Niculescu Duvaz-D; Davies L; Springer CJ

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Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

机译：用于抗体和基因指导的酶前药治疗的前药（ADEPT和GDEPT）。

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Antibody- and gene-directed enzyme prodrug therapy are two-step targeting strategies designed to improve the selectivity of antitumour agents. The approaches are based on the activation of specially designed prodrugs by antibody-enzyme conjugates targeted to tumour-associated antigens (ADEPT) or by enzymes expressed by exogenous genes in tumour cells (GDEPT). Herein the design, synthesis, physico-chemical and biological properties, kinetics and clinical trials of the prodrugs and the enzymes carboxypeptidase G2 and nitroreductase are reviewed for ADEPT and GDEPT.

机译：抗体和基因指导的酶前药治疗是两步靶向策略，旨在提高抗肿瘤药的选择性。这些方法基于专门设计的前药通过靶向肿瘤相关抗原的抗体-酶偶联物（ADEPT）或肿瘤细胞中外源基因表达的酶（GDEPT）的激活。本文对ADEPT和GDEPT的前药和羧肽酶G2和硝基还原酶的设计，合成，理化和生物学性质，动力学和临床试验进行了综述。

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来源
《Anti-Cancer Drug Design》 |1999年第6期|共22页
作者
Niculescu Duvaz-I; Friedlos F; Niculescu Duvaz-D; Davies L; Springer CJ;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Gene Therapy; Immunotherapy; Neoplasms; Prodrugs; Antibodies; Neoplasm; 基因疗法; 免疫疗法; 肿瘤; 药物前体;

机译：Gene Therapy;Immunotherapy;Neoplasms;Prodrugs;Antibodies;Neoplasm;基因疗法;免疫疗法;肿瘤;药物前体;

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1. Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT). [J] . Niculescu Duvaz-I, Friedlos F, Niculescu Duvaz-D, Anti-Cancer Drug Design . 1999,第6期

机译：用于抗体和基因指导的酶前药治疗的前药（ADEPT和GDEPT）。
2. Isophosphoramide Mustard Analogues as Prodrugs for Anticancer Gene-directed Enzyme-prodrug Therapy (GDEPT) [J] . Acta biochimica Polonica . 2002,第1期

机译：异磷酰胺芥末类似物作为抗癌基因指导的酶前药治疗（GDEPT）的前药
3. Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT). [J] . Hay MP, Wilson WR, Denny WA Bioorganic and Medicinal Chemistry Letters . 1999,第24期

机译：烯二炔的氨基甲酸硝基苄酯前药，用于硝基还原酶基因指导的酶前药治疗（GDEPT）。
4. Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy [C] . Catherine E. Christie, Genesis Zamora, Young J. Kwon, Conference on Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics . 2015

机译：巨噬细胞介导的PCI增强基因指导的酶前药治疗
5. Design and synthesis of multifunctional polymeric micelles for gene-directed enzyme prodrug therapy. [D] . Sawdon, Alicia J. 2014

机译：设计和合成用于基因定向酶前药治疗的多功能聚合物胶束。
6. Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy) [O] . William A Denny 2003

机译：基因导向酶前药疗法（自杀基因疗法）的前药
7. Isophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy (GDEPT). [O] . Konrad Misiura, Daria Szymanowicz, Halina Kuśnierczyk, 2002

机译：异磷酰胺芥末类似物作为抗癌基因定向酶 - 前药治疗（GDEPT）的前药。
8. Chimeric Enzyme/Prodrug Therapy as Novel Gene Therapy for Breast Cancer [R] . Cooper, D. L. 1997

机译：嵌合酶/前药治疗作为乳腺癌的新型基因治疗

Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT).

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