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首页> 外文期刊>Annals of epidemiology >Smoking and the risk of age-related macular degeneration: a meta-analysis.
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Smoking and the risk of age-related macular degeneration: a meta-analysis.

机译：吸烟和与年龄有关的黄斑变性的风险：一项荟萃分析。

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PURPOSE: Some studies were undertaken to evaluate the association between cigarette smoking and age-related macular degeneration (AMD). This meta-analysis summarized the risk estimate of smoking and AMD and provided robust evidence for the association. METHODS: Relevant studies were identified by searching PubMed and MEDLINE (from 1966 to June 2007) and reviewing the reference lists of key articles. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated. Study-specific risk estimates were pooled using a random-effects model. RESULTS: Five prospective cohort and eight case-control studies met our inclusion criteria. Ever smoking was statistically significant associated with increased risk of AMD among cohort studies (RR, 1.61; 95% CI, 1.01-2.57) or case-control studies (RR, 1.76; 95% CI, 1.56-1.99). Current smokers were at higher risk of AMD than past smokers. Both geographic atrophy (GA) and neovascular AMD (NV) are subtypes of AMD. A significant relationship was found between smoking and GA risk. Smoking increased the risk of NV, with marginal nonsignificance (RR, 1.47; 95% CI, 0.92-2.37) in cohort studies and significance in case-control studies (RR, 1.96; 95% CI, 1.69-2.27). CONCLUSIONS: This meta-analysis indicated smoking, especially current smoking, was significantly associated with increased risks of AMD and its subtypes.
机译：目的：进行了一些研究，以评估吸烟与年龄相关性黄斑变性（AMD）之间的关系。这项荟萃分析总结了吸烟和AMD的风险估计，并为相关性提供了有力的证据。方法：通过检索PubMed和MEDLINE（从1966年至2007年6月）并查看关键文章的参考文献清单，确定相关研究。计算总的相对风险比（RR）或优势比（OR）和95％置信区间（CI）。使用随机效应模型汇总特定于研究的风险估计。结果：五项前瞻性队列研究和八项病例对照研究符合我们的纳入标准。在队列研究（RR，1.61; 95％CI，1.01-2.57）或病例对照研究（RR，1.76; 95％CI，1.56-1.99）中，曾经吸烟与增加AMD风险相关，具有统计学意义。当前吸烟者比过去吸烟者患AMD的风险更高。地理萎缩（GA）和新生血管AMD（NV）都是AMD的亚型。发现吸烟与GA风险之间存在显着关系。吸烟增加了NV的风险，在队列研究中具有边缘性无意义（RR，1.47; 95％CI，0.92-2.37），在病例对照研究中具有显着性（RR，1.96; 95％CI，1.69-2.27）。结论：这项荟萃分析表明吸烟，尤其是目前的吸烟与AMD及其亚型的风险增加显着相关。

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