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首页> 外文期刊>Annals of epidemiology >Past medical history and pancreatic cancer risk: Results from a multicenter case-control study.
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Past medical history and pancreatic cancer risk: Results from a multicenter case-control study.

机译：既往病史和胰腺癌风险：多中心病例对照研究的结果。

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PURPOSE: To investigate risk factors that may be linked to pancreatic cancer. METHODS: We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. RESULTS: After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82). CONCLUSIONS: Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer.
机译：目的：调查可能与胰腺癌有关的危险因素。方法：我们设计了一个多中心的基于病例的病例对照研究（823例，1679例对照患者），并使用通用方案和问卷调查收集了数据。参与中心位于澳大利亚，加拿大，荷兰和波兰。结果：校正混杂因素后，胰腺炎的阳性病史与胰腺癌有关（几率[OR]为4.68; 95％置信区间[95％CI]为2.23-9.84）。重度吸烟者的风险尤其高（OR，15.4; 95％CI，3.18-74.9）。糖尿病患者罹患胰腺癌的风险增加（OR为2.16; 95％CI为1.60-2.91）。患糖尿病的第一年，该风险最高（OR，6.68; 95％CI，3.56-12.6），并随时间降低。过敏史与胰腺癌风险降低相关（OR，0.64; 95％CI，0.50-0.82）。结论：新诊断为糖尿病的患者和胰腺炎患者，特别是大量吸烟者，罹患胰腺癌的风险增加。除了是危险因素外，这些疾病还可能是潜在胰腺癌的早期表现。过敏史可降低胰腺癌的风险。

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