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首页> 外文期刊>Annals of epidemiology >Does chocolate intake during pregnancy reduce the risks of preeclampsia and gestational hypertension?
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Does chocolate intake during pregnancy reduce the risks of preeclampsia and gestational hypertension?

机译：怀孕期间摄入巧克力可以降低先兆子痫和妊娠高血压的风险吗？

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PURPOSE: Chocolate consumption is associated with favorable levels of blood pressure and other cardiovascular disease risk markers. We analyzed a prospective cohort study to determine whether regular chocolate intake during pregnancy is associated with reduced risks of preeclampsia and gestational hypertension (GH). METHODS: Subjects were recruited from 13 prenatal care practices in Connecticut (1988-1991). In-person interviews were administered at <16 weeks' gestation to ascertain risk factors for adverse pregnancy outcomes. Hospital delivery and prenatal records were abstracted to classify preeclampsia (n = 58), GH (n = 158), and normotensive pregnancies (n = 2351). Chocolate consumption (servings/week) during the first and third trimesters was ascertained at initial interview and immediately postpartum, respectively. Consumers of less than 1 serving/week comprised the referent group. Adjusted odds ratios (aORs) were estimated by the use of logistic regression. RESULTS: Chocolate intake was more frequent among normotensive (80.7%) than preeclamptic (62.5%) or GH women (75.8%), and associated with reduced odds of preeclampsia (first trimester: aOR, 0.55; 95% confidence interval [95% CI], 0.32-0.95; third trimester: aOR, 0.56; 95% CI, 0.32-0.97). Only first trimester intake was associated with reduced odds of GH (aOR,0.65; 95% CI, 0.45-0.87). CONCLUSIONS: These findings provide additional evidence of the benefits of chocolate. Prospective studies are needed to confirm and delineate protective effects of chocolate intake on risk of preeclampsia.
机译：用途：食用巧克力与血压和其他心血管疾病危险指标的有利水平有关。我们分析了一项前瞻性队列研究，以确定怀孕期间定期摄入巧克力与子痫前期和妊娠高血压（GH）的风险降低是否相关。方法：对象是从康涅狄格州（1988-1991年）的13种产前护理实践中招募的。妊娠<16周时进行了面谈，以确定不良妊娠结局的危险因素。提取医院分娩和产前记录以对先兆子痫（n = 58），GH（n = 158）和血压正常妊娠（n = 2351）进行分类。分别在初次面试和产后立即确定头三个月和三个月的巧克力消费量（每周食用量）。每周少于1份的消费者组成了参考人群。调整后的优势比（aOR）通过使用Logistic回归进行估算。结果：正常血压（80.7％）的巧克力摄入量比先兆子痫（62.5％）或GH妇女（75.8％）更高，并且与先兆子痫几率降低相关（早孕期：aOR，0.55; 95％置信区间[95％CI ，0.32-0.95;中期：aOR，0.56; 95％CI，0.32-0.97）。仅孕早期摄入与GH几率降低相关（aOR，0.65; 95％CI，0.45-0.87）。结论：这些发现为巧克力的益处提供了更多的证据。需要进行前瞻性研究，以确认和描述摄入巧克力对先兆子痫风险的保护作用。

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