...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of epidemiology >Sunburns and risk of cutaneous melanoma: does age matter? A comprehensive meta-analysis.
【24h】

Sunburns and risk of cutaneous melanoma: does age matter? A comprehensive meta-analysis.

机译：晒伤和皮肤黑色素瘤的风险：年龄重要吗？全面的荟萃分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: Sunburns are an important risk factor for melanoma and those occurring in childhood are often cited as posing the greatest risk. We conducted a meta-analysis to quantify the magnitude of association for melanoma and sunburns during childhood, adolescence, adulthood and over a lifetime. METHODS: After reviewing over 1300 article titles and evaluating 270 articles in detail, we pooled odds ratios from 51 independent study populations for "ever" sunburned and risk of cutaneous melanoma. Among these, 26 studies reported results from dose-response analyses. Dose-response analyses were examined using both fixed-effects models and Bayesian random-effects models. RESULTS: An increased risk of melanoma was seen with increasing number of sunburns for all time-periods (childhood, adolescence, adulthood, and lifetime). In an attempt to understand how risk between life-periods compares, we also report these same linear models on a scale of five sunburns per decade for each life-period. The magnitude of risk for five sunburns per decade is highest for adult and lifetime sunburns. CONCLUSIONS: Overall, these results show an increased risk of melanoma with increasing number of sunburns during all life-periods, not just childhood. Prevention efforts should focus on reducing sunburns during all life-periods.
机译：目的：晒伤是黑色素瘤的重要危险因素，而儿童时期发生的晒伤通常被认为构成最大的危险。我们进行了荟萃分析，以量化在儿童期，青春期，成年期以及一生中黑色素瘤和晒伤的关联程度。方法：在回顾了1300篇文章标题并详细评估了270篇文章之后，我们汇总了51个独立研究人群中“曾经”被晒伤和皮肤黑色素瘤风险的比值比。其中，有26个研究报告了剂量反应分析的结果。使用固定效应模型和贝叶斯随机效应模型检查剂量反应分析。结果：在所有时间段（童年，青春期，成年和一生），日光灼伤的人数增加，导致黑色素瘤的风险增加。为了理解生命周期之间的风险如何进行比较，我们还报告了这些相同的线性模型，每个生命周期的比例为每十年五个晒斑。成人和终生晒伤每十年发生五次晒伤的风险最高。结论：总的来说，这些结果表明，在所有生命周期中（不仅是儿童时期），随着日晒次数的增加，黑色素瘤的风险也增加。预防工作应着重减少所有生命周期中的晒伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号