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首页> 外文期刊>Annals of epidemiology >HDL-cholesterol and incidence of breast cancer in the ARIC cohort study.
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HDL-cholesterol and incidence of breast cancer in the ARIC cohort study.

机译：ARIC队列研究中的HDL-胆固醇和乳腺癌的发生率。

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PURPOSE: An association of low plasma HDL-cholesterol with risk of breast cancer has been suggested by multiple studies; the evidence, however, is not conclusive. We examined the possible association of low HDL-cholesterol with incidence of breast cancer using data from the Atherosclerosis Risk in Communities Study (ARIC) cohort, a prospective study of a randomly selected sample of women and men from four U.S. communities. METHODS: Among 7,575 female members of the ARIC cohort, 359 cases of incident breast cancer were ascertained during the follow-up from 1987 through 2000. RESULTS: In analysis adjusted for age, race, body mass index, smoking, and reproductive variables, we observed no association of low baseline HDL-cholesterol (<50mg/dL) with incident breast cancer in the total sample (hazard ratio [HR]=1.08 [95% confidence interval (CI), 0.84-1.40]) and a modest association (HR=1.67 [95% CI, 1.06-2.63]) among women who were premenopausal at baseline. No association was observed among women who were postmenopausal at baseline. Removal from analysis of the first 5 years of follow-up did not appreciably change the observed associations. CONCLUSION: Results of our study suggest that low HDL-cholesterol among premenopausal women may be a marker of increased breast cancer risk.
机译：目的：多项研究提示低血浆HDL-胆固醇与患乳腺癌的风险有关;但是，证据尚无定论。我们使用来自社区动脉粥样硬化风险研究（ARIC）队列的数据检验了低HDL-胆固醇与乳腺癌发病率之间的可能关系，该研究是一项对来自美国四个社区的男女随机抽样进行的前瞻性研究。方法：1987年至2000年的随访期间，在ARIC队列的7575名女性成员中，确定了359例乳腺癌事件。结果：在对年龄，种族，体重指数，吸烟和生殖变量进行校正的分析中，我们观察到总样本中低基线HDL-胆固醇（<50mg / dL）与乳腺癌的发生率无相关性（危险比[HR] = 1.08 [95％置信区间（CI），0.84-1.40]），且相关性不强（在基线绝经前的女性中，HR = 1.67 [95％CI，1.06-2.63]。在基线绝经后的女性中未观察到关联。从随访的前5年分析中删除并没有明显改变所观察到的关联。结论：我们的研究结果表明，绝经前女性的低HDL-胆固醇可能是增加患乳腺癌风险的标志。

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