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首页> 外文期刊>Annals of epidemiology >Risk of cardiovascular mortality in relation to optimal low-density lipoprotein cholesterol combined with hypertriglyceridemia: is there a difference by gender?
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Risk of cardiovascular mortality in relation to optimal low-density lipoprotein cholesterol combined with hypertriglyceridemia: is there a difference by gender?

机译：最佳低密度脂蛋白胆固醇与高甘油三酯血症相关的心血管疾病死亡风险：性别是否存在差异？

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PURPOSE: The objectives of the present study were to determine whether an optimal low-density lipoprotein cholesterol (LDL-C) combined with hypertriglyceridemia was associated with cardiovascular disease (CVD) mortality and whether these associations differ by gender. METHODS: A cohort of 2903 U.S. adults aged >/=45 years (men) and >/=55 years (women) at baseline (1988-1994) was followed through December 2006 for CVD mortality. Baseline data were collected through the Third National Health and Nutrition Examination Survey (NHANES III). The definitions of high LDL-C and high triglycerides (TG) (hypertriglyceridemia) levels were based on the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. Cox proportional hazard models were used to estimate the hazard ratio (HR) with 95% confidence interval (CI) of death. RESULTS: After adjusting for age, race/ethnicity, and traditional CVD risk factors, the risk of CVD death was approximately two times as high among women with optimal LDL-C/hypertriglyceridemia (2.42, 95% CI = 1.35-4.33) compared to women with optimal LDL-Cormal TG. In contrast, no significant difference was found among men on this comparison. CONCLUSIONS: Judging from this study, hypertriglyceridemia is associated with an increased risk of CVD mortality in women but not in men. The association is independent of abnormal LDL-C effect.
机译：目的：本研究的目的是确定最佳低密度脂蛋白胆固醇（LDL-C）合并高甘油三酸酯血症是否与心血管疾病（CVD）死亡率相关，以及这些相关性是否因性别而异。方法：直到2006年12月为止，以基线期（1988-1994）的年龄≥/ = 45岁（男性）和≥/ = 55岁（女性）的2903名美国成年人为研究对象，研究其CVD死亡率。基线数据是通过第三次全国健康与营养检查调查（NHANES III）收集的。高LDL-C和高甘油三酸酯（TG）（高甘油三酯血症）水平的定义是基于国家胆固醇教育计划成人治疗小组III（NCEP ATP III）指南。使用Cox比例风险模型来估计具有95％的置信区间（CI）的死亡风险比（HR）。结果：在调整了年龄，种族/民族和传统的CVD危险因素后，具有最佳LDL-C /高甘油三酯血症的女性（2.42，95％CI = 1.35-4.33）的CVD死亡风险大约是其两倍。 LDL-C /正常TG最佳的女性。相反，在此比较中，男性之间没有发现显着差异。结论：从这项研究来看，高甘油三酯血症与女性心血管疾病死亡风险增加有关，而与男性无关。该关联与异常的LDL-C效应无关。

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