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首页> 外文期刊>Annals of epidemiology >Frequency of human papillomavirus infection, coinfection, and association with different risk factors in Colombia.
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Frequency of human papillomavirus infection, coinfection, and association with different risk factors in Colombia.

机译：在哥伦比亚，人类乳头瘤病毒感染，合并感染的频率以及与不同危险因素的关联。

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PURPOSE: The aims of this study were to provide new insights into infection patterns of six high-risk human papillomaviruses (HR-HPV-16, -18, -31, -33, -45, and -58) and two low-risk HPV types (LR-HPV-6 and -11), their association with risk factors and coinfection. METHODS: Cervical samples of 2110 women were tested for the presence of HPV-DNA by polymerase chain reaction. Statistical analyses were performed to determine viral-type frequencies in single and multiple infections and association between infection and different risk factors. RESULTS: HPV-16 was the most prevalent type among the studied population, followed by HPV-31. This last viral type showed a variable distribution between the different cities evaluated. The results showed distinct type-specific distributions among regions and a high association between absence of pregnancies, cities as Girardot and Leticia, the indigenous ethnicity, and coinfection. CONCLUSIONS: The results showed a variable distribution of HPV types according to the geographical region analyzed. In addition, data suggest that some sociodemographic-factors such as ethnicity, number of pregnancies, lifetime number of sexual partners, and geographic region were significantly associated, and our results showed little differences between single and multiple infections by HPV with regard to risk factors. Furthermore, these results provide relevant information that will allow assessing in further studies the impact that vaccination programs on these populations and the selective pressure would have on the distribution of HPV types.
机译：目的：本研究的目的是提供对六种高危人类乳头瘤病毒（HR-HPV-16，-18，-31，-33，-45和-58）和两种低风险的感染模式的新见解。 HPV类型（LR-HPV-6和-11）与危险因素和合并感染的关系。方法：通过聚合酶链反应检测2110名妇女的宫颈样本中是否存在HPV-DNA。进行统计分析以确定单次和多次感染中的病毒类型频率以及感染与不同危险因素之间的关联。结果：HPV-16是研究人群中最普遍的类型，其次是HPV-31。最后一种病毒类型显示了所评估的不同城市之间的变量分布。结果表明，不同地区之间的类型特定分布不同，并且没有怀孕，吉拉尔多（Girardot）和莱蒂西亚（Leticia）等城市，土著民族和共同感染之间存在高度关联。结论：结果表明，HPV类型根据所分析的地理区域呈可变分布。此外，数据表明，某些社会人口统计学因素（如种族，怀孕次数，性伴侣的终生人数和地理区域）显着相关，我们的结果表明，HPV一次或多次感染在危险因素方面差异不大。此外，这些结果提供了相关信息，可以在进一步研究中评估疫苗接种计划对这些人群的影响以及选择压力对HPV类型分布的影响。

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