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首页> 外文期刊>Annals of epidemiology >Association of serum sex steroid hormone hemodilution and body mass index among healthy postmenopausal women.
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Association of serum sex steroid hormone hemodilution and body mass index among healthy postmenopausal women.

机译：健康绝经后妇女血清性类固醇激素血液稀释与体重指数的关联。

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PURPOSE: Hemodilution refers to reduced concentrations of analytes in the blood secondary to increased fluid volume. Given that obesity is associated with expanded vascular volume, hemodilution may result in a lower ratio of blood concentrations of analytes among heavier subjects. Assessing the relationship of hormone concentration to total mass varies by body mass index (BMI) is etiologically important because obesity is related to hormone metabolism and cancer risk. METHODS: We evaluated data for 194 postmenopausal controls in an endometrial cancer case-control study. Height, weight, and serum hormone concentrations were measured previously. We estimated serum hormone mass from concentration based on estimates of calculated plasma volume. We assessed the effect of BMI on relationships of sex steroid hormone concentration and mass using multivariate linear regression. RESULTS: Higher BMI was associated with increased estrone, estrone sulfate, estradiol, and albumin-bound estradiol concentrations and masses (p-trend
机译：目的：血液稀释是指继输液量增加后血液中分析物浓度降低。鉴于肥胖与扩张的血管容量有关，血液稀​​释可能导致较重的受试者中分析物血液浓度的比例降低。在病因学上，评估激素浓度与总质量的关系因体重指数（BMI）而异，因为肥胖与激素代谢和癌症风险有关。方法：我们在子宫内膜癌病例对照研究中评估了194个绝经后对照的数据。身高，体重和血清激素浓度以前已经过测量。我们根据计算血浆量的估计值，根据浓度估计血清激素质量。我们使用多元线性回归评估了BMI对性类固醇激素浓度与质量关系的影响。结果：较高的BMI与雌酮，硫酸雌酮，雌二醇和结合白蛋白的雌二醇浓度和质量增加有关（p-趋势

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