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首页> 外文期刊>Annals of epidemiology >The influence of being overweight on the relationship between shift work and increased total cholesterol level.
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The influence of being overweight on the relationship between shift work and increased total cholesterol level.

机译：超重对轮班工作和总胆固醇水平升高之间关系的影响。

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PURPOSE: The aim of this study was to clarify the influence of shift work on serum total cholesterol (T-Cho) levels according to body mass index (BMI) at entry in Japanese male workers. METHODS: A 14-year prospective cohort study was conducted in day workers (n = 4079) and alternating shift workers (n = 2807) who received annual health check-ups between 1991 and 2005 in a Japanese steel company. The association between job schedule and increases in T-Cho was investigated using multivariate pooled logistic regression analyses with age, BMI, lifestyle (smoking habit, drinking habit, habitual exercise), and the results of blood chemistries (creatinine, glycosylated hemoglobin A1c, aspartic aminotransferase, gamma-glutamyl transpeptidase, uric acid) serving as covariates in those who were not overweight (BMI < 25 kg/m(2), n = 5082) and overweight (BMI >/= 25 kg/m(2), n = 1804) at entry, respectively. The endpoints in the study were either a 20%, 25%, 30%, 35%, 40%, or 45% increase in T-Cho during the period of observation compared to T-Cho at entry. RESULTS: In subjects who were not overweight at entry, alternating shift work was associated significantly with five serum T-Cho endpoints (>/=20%: odds ratio [OR] = 1.15, 95% confidence interval [CI)] = 1.05, 1.26; >/=25%: OR = 1.17, 95% CI = 1.05, 1.31; >/=35%: OR = 1.24, 95% CI = 1.05, 1.46; >/=40%: OR = 1.30, 95% CI = 1.06, 1.61; >/=45%: OR = 1.31, 95% CI = 1.01, 1.71). However, alternating shift work was not associated with any of the six T-Cho endpoints in subjects who were overweight at entry. CONCLUSIONS: In the present study, shift work was shown to be a potential risk factor for increased T-Cho in non-overweight Japanese male workers. However, we did not obtain a consistent association between shift work and an increase in T-Cho levels in overweight subjects. The results suggest that the effect of shift work on lipid regulation may be influenced by BMI.
机译：目的：本研究的目的是根据进入日本男性工人时的体重指数（BMI），阐明轮班工作对血清总胆固醇（T-Cho）水平的影响。方法：对一家日本钢铁公司在1991年至2005年期间接受年度健康检查的日间工人（n = 4079）和轮班工人（n = 2807）进行了为期14年的前瞻性队列研究。使用多变量汇总Logistic回归分析调查了工作时间表与T-Cho增高之间的相关性，包括年龄，BMI，生活方式（吸烟习惯，饮酒习惯，习惯运动）以及血液化学结果（肌酐，糖化血红蛋白A1c，天冬氨酸）在未超重（BMI <25 kg / m（2），n = 5082）和超重（BMI> / = 25 kg / m（2），n）的人群中，氨基转移酶，γ-谷氨酰转肽酶，尿酸作为协变量= 1804）。与进入时的T-Cho相比，研究的终点是观察期间T-Cho的增加20％，25％，30％，35％，40％或45％。结果：在入组时未超重的受试者中，交替轮班与五个血清T-Cho终点显着相关（> / = 20％：优势比[OR] = 1.15，95％置信区间[CI]] = 1.05， 1.26; > / = 25％：OR = 1.17，95％CI = 1.05，1.31; > / = 35％：OR = 1.24，95％CI = 1.05，1.46; > / = 40％：OR = 1.30，95％CI = 1.06，1.61; > / = 45％：OR = 1.31，95％CI = 1.01，1.71）。但是，轮班工作与进入时超重的受试者的六个T-Cho终点均不相关。结论：在本研究中，轮班工作被证明是非超重日本男性工人T-Cho增加的潜在危险因素。但是，在超重受试者中，轮班工作与T-Cho水平升高之间没有一致的关联。结果表明，轮班工作对脂质调节的影响可能受到BMI的影响。

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