...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of epidemiology >Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: A meta-analysis
【24h】

Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: A meta-analysis

机译：食管鳞状细胞癌中人乳头瘤病毒16型和18型的荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: A possible carcinogenic role of human papillomavirus (HPV) has been investigated in esophageal squamous cell carcinoma (ESCC) for nearly 30 years with mixed results. We performed a meta-analysis to assess the prevalence of "high-risk" HPV, HPV-16/18, in this disease. We also evaluated the association between infection with HPV-16/18 and ESCC risk by meta-analysis of case-control studies. Methods: Eligible studies published up to September 30, 2012 were retrieved via both computer searches of MEDLINE and EMBASE and manual review of references. A random-effects model was used to calculate summary prevalence and odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results: A total of 5755 cases of ESCC from 68 studies were included in this meta-analysis. Overall, 11.67% (95% CI, 7.74%-16.21%) of ESCC cases harbored HPV-16 and 1.82% (95% CI, 0.90%-2.95%) harbored HPV-18. In addition, meta-analysis of 10 case-control studies showed a significant increase in ESCC risk with HPV-16 infection (summary ORs= 3.55; 95% CIs, 2.05%-6.14%). However, this increased risk in ESCC was not made for HPV-18 infection (summary ORs= 1.25; 95% CIs, 0.46%-3.43%). Conclusions: This meta-analysis indicated that HPV-16 and -18 can be detected in ESCC. HPV-16, but not HPV-18, is significantly associated with the risk of ESCC. However, it is early to conclude that both types of HPV are involved in esophageal carcinogenesis.
机译：目的：研究人乳头瘤病毒（HPV）在食管鳞状细胞癌（ESCC）中可能的致癌作用近30年，结果不一。我们进行了荟萃分析，以评估该疾病中“高危” HPV HPV-16 / 18的患病率。我们还通过病例对照研究的荟萃分析评估了HPV-16 / 18感染与ESCC风险之间的关联。方法：通过计算机检索MEDLINE和EMBASE以及人工查阅参考文献，检索截至2012年9月30日的合格研究。使用随机效应模型来计算汇总患病率和优势比（OR）以及相应的95％置信区间（CI）。结果：这项荟萃分析纳入了来自68项研究的5755例ESCC病例。总体而言，ESCC病例中有11.67％（95％CI，7.74％-16.21％）带有HPV-16，而1.82％（95％CI，0.90％-2.95％）带有HPV-18。此外，对10个病例对照研究的荟萃分析显示，HPV-16感染的ESCC风险显着增加（总OR = 3.55; 95％CI为2.05％-6.14％）。然而，这种增加的ESCC风险并非针对HPV-18感染（总OR = 1.25; 95％CI，0.46％-3.43％）。结论：这项荟萃分析表明在ESCC中可以检测到HPV-16和-18。 HPV-16而非HPV-18与ESCC风险显着相关。但是，现在就得出结论，两种类型的HPV都与食管癌变有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号