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首页> 外文期刊>Annals of epidemiology >Epidemiologic evidence for different roles of ultraviolet a and B radiation in melanoma mortality rates.
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Epidemiologic evidence for different roles of ultraviolet a and B radiation in melanoma mortality rates.

机译：流行病学证据表明紫外线A和B辐射在黑色素瘤死亡率中的不同作用。

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PURPOSE: The action spectrum of ultraviolet radiation mainly responsible for melanoma induction is unknown, but evidence suggests it could be ultraviolet A (UVA), which has a different geographic distribution than ultraviolet B (UVB). This study assessed whether melanoma mortality rates are more closely related to the global distribution of UVA or UVB.METHODS: UVA and UVB radiation and age-adjusted melanoma mortality rates were obtained for all 45 countries reporting cancer data to the World Health Organization. Stratospheric ozone data were obtained from NASA satellites. Average population skin pigmentation was obtained from skin reflectometry measurements.RESULTS: Paradoxically, melanoma mortality rates decreased with increasing UVB in men (r = -0.48, p < 0.001), and women (r = -0.57, p < 0.001), and with increasing UVA in both sexes. By contrast, rates were positively associated with increasing UVA/UVB ratio in men (r = + 0.49, p < 0.001) and women (r = + 0.55, p < 0.001). After multiple adjustment that included controlling for skin pigmentation, only UVA was associated with melanoma mortality rates in men (p < 0.02) with a suggestive but non-significant trend present in women (p = 0.12).CONCLUSIONS: UVA radiation was associated with melanoma mortality rates after controlling for UVB and average pigmentation. The results require confirmation in observational studies.
机译：目的：主要负责诱导黑色素瘤的紫外线辐射的作用谱尚不清楚，但有证据表明它可能是紫外线A（UVA），其地理分布与紫外线B（UVB）不同。这项研究评估了黑色素瘤死亡率是否与UVA或UVB的全球分布更密切相关。方法：获得了向世界卫生组织报告癌症数据的所有45个国家的UVA和UVB辐射以及年龄校正的黑色素瘤死亡率。平流层臭氧数据是从NASA卫星获得的。结果：自相矛盾的是，黑色素瘤死亡率随着男性（r = -0.48，p <0.001）和女性（r = -0.57，p <0.001）和UVB的升高而降低。两性中的UVA增加。相比之下，男性（r = + 0.49，p <0.001）和女性（r = + 0.55，p <0.001）的患病率与UVA / UVB比率增加呈正相关。经过多次调整（包括控制皮肤色素沉着）后，只有UVA与男性黑色素瘤死亡率相关（p <0.02），女性存在提示性但无显着趋势（p = 0.12）。结论：UVA辐射与黑色素瘤相关控制UVB和平均色素沉着后的死亡率。结果需要观察研究的证实。

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