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首页> 外文期刊>Annals of epidemiology >Biologic and social determinants of sequelae and long-term survival of pediatric HIV in Romania.
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Biologic and social determinants of sequelae and long-term survival of pediatric HIV in Romania.

机译：罗马尼亚小儿HIV后遗症和长期生存的生物学和社会决定因素。

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PURPOSE: The aim of the study is to investigate the effect of social context and clinical factors on survival in a cohort of 333 children to identify issues useful in the treatment and care of human immunodeficiency virus (HIV)-infected youth in developing countries. METHODS: A prospective cohort study design was used, and data were gathered at baseline and 1-year follow-up. The study cohort consisted of children given a diagnosis of HIV between 1995 and 1999 and receiving medical care in Constanta, Romania. Data were examined by means of multivariate Cox regression analysis models. RESULTS: The majority of the cohort were in the moderate (41%) or severe (40%) stages of HIV at baseline. Multivariate analysis indicated that social-context factors were the most significant determinants of HIV survival. The hazard for death for those with mothers or fathers with a higher level of education was approximately one quarter (relative hazard, 0.3-0.4; confidence interval, 0.1-1.0) that for a parent with a lowerlevel of education. Subjects with employed mothers were four times more likely to survive than subjects with unemployed mothers. CONCLUSIONS: Results suggest that recognition of social-context risk factors for HIV disease progression and survival is important in developing countries, as it is in developed countries.
机译：目的：该研究的目的是调查333名儿童队列中的社会背景和临床因素对生存的影响，以发现可用于治疗和护理发展中国家感染人类免疫缺陷病毒（HIV）的青年的问题。方法：采用前瞻性队列研究设计，并在基线和1年随访中收集数据。该研究队列包括1995年至1999年之间被诊断出患有HIV并在罗马尼亚康斯坦察接受医疗的儿童。通过多元Cox回归分析模型检查数据。结果：大多数队列在基线时处于中度（41％）或严重（40％）HIV阶段。多变量分析表明，社会背景因素是艾滋病毒生存的最重要决定因素。母亲或父亲受教育程度较高的人的死亡危险约为父母教育程度较低的人的四分之一（相对危险度为0.3-0.4;置信区间为0.1-1.0）。有受雇母亲的受试者的存活可能性是有失业母亲的受试者的四倍。结论：结果表明，与发达国家一样，认识到艾滋病毒疾病进展和生存的社会背景危险因素也很重要。

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