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首页> 外文期刊>Annals of epidemiology >Sex differences in the association between birth weight and total cholesterol. A meta-analysis.
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Sex differences in the association between birth weight and total cholesterol. A meta-analysis.

机译：出生体重和总胆固醇之间关联的性别差异。荟萃分析。

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PURPOSE: Determine whether a sex difference exists in the association between birth weight and total cholesterol later in life. METHODS: Meta-analysis of within-study differences in regression coefficients of cholesterol on birth weight. RESULTS: A total of 34 regression coefficients from 30 studies were included in the analyses; these provided data on 33,650 males and 23,129 females. There was evidence that the inverse association between birth weight and total cholesterol was stronger in males compared to females. The pooled within-study difference in age-adjusted regression coefficients was -0.03 mmol/l (-0.06, -0.01), p 0.02 and the pooled within-study difference in age and body mass index adjusted regression coefficients was -0.04 mmol/l (-0.07, -0.02), p = 0.002. There was no evidence of heterogeneity in these meta-analyses (both p values > 0.6). CONCLUSIONS: These results provide some evidence for a sex difference in the birth weight-total cholesterol association. This is consistent with studies of fetal growth which suggest that birth size reflects different biological processes for females and males. However, other very large studies are required to confirm this finding.
机译：目的：确定出生后体重与总胆固醇之间的关系是否存在性别差异。方法：荟萃分析研究胆固醇对出生体重的回归系数的差异。结果：来自30个研究的34个回归系数被纳入分析。这些提供了33,650名男性和23,129名女性的数据。有证据表明，与女性相比，男性的出生体重和总胆固醇之间的逆相关性更强。年龄调整后回归系数的汇总研究内差异为-0.03 mmol / l（-0.06，-0.01）p = 0.02，年龄和体重指数调整后回归的汇总研究内差异为-0.04 mmol / l （-0.07，-0.02），p ＝ 0.002。在这些荟萃分析中没有证据显示异质性（均为p值> 0.6）。结论：这些结果为出生体重与总胆固醇之间的性别差异提供了一些证据。这与胎儿生长的研究一致，该研究表明，出生年龄反映了男女的不同生物学过程。但是，还需要其他非常大的研究来证实这一发现。

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