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首页> 外文期刊>Annals of epidemiology >Trichomoniasis in pregnancy and mental retardation in children.
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Trichomoniasis in pregnancy and mental retardation in children.

机译：妊娠毛滴虫病和儿童智力低下。

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PURPOSE: Trichomoniasis is a highly prevalent sexually transmitted infection and is associated with premature rupture of membranes, preterm birth, and low birth weight. This study examines the association between maternal trichomoniasis and intellectual disability (ID) in children. METHODS: This study utilized linked maternal, infant, and child records for 134,596 Medicaid-insured singleton births in South Carolina from 1996 through 2002. Data were obtained from Medicaid billing records, birth certificates, and administrative data from the South Carolina Department of Education (DOE) and the Department of Disabilities and Special Needs (DDSN). Pregnancies during which women were diagnosed with urinary tract infection, chlamydia, gonorrhea, or vulvovaginal candidiasis were excluded, as were children diagnosed with a known cause of mental retardation. Odds of diagnosed ID in children were modeled using population averaged generalized estimating equation models. RESULTS: Controlling for potential confounders, women with trichomoniasis were significantly more likely to have a child with ID (hazard ratio [HR] = 1.28; 95% confidence interval [CI], 1.12-1.46). The association was stronger for moderate to severe ID documented by the school system or DDSN (HR = 1.84; 95% CI, 1.35-2.51). Second-trimester trichomoniasis was associated with more than a three-fold increase in the odds a child was identified as trainable mentally handicapped or profoundly mentally handicapped in the public school system, or was receiving ID services from DDSN. There was not a significant difference in the risk of ID in children of women with treated versus untreated trichomoniasis. CONCLUSION: Maternal trichomoniasis may be a preventable risk factor for ID.
机译：目的：毛滴虫病是一种高度流行的性传播感染，与胎膜早破，早产和低出生体重有关。这项研究探讨了儿童滴虫病与母亲智力障碍（ID）之间的关联。方法：本研究利用1996年至2002年在南卡罗来纳州进行的134,596例由医疗补助保险的单胎出生的母亲，婴儿和儿童的相关记录。数据来自南卡罗来纳州教育部的医疗补助帐单记录，出生证明和行政数据（美国能源部（DOE）和残疾人与特殊需求部（DDSN）。诊断为患有尿路感染，衣原体，淋病或念珠菌性念珠菌病的孕妇被排除在外，诊断为已知智力障碍的儿童也被排除在外。使用人口平均广义估计方程模型对儿童诊断出的ID的可能性进行建模。结果：控制潜在的混杂因素，毛滴虫病的妇女生育ID的孩子的可能性更高（危险比[HR] = 1.28; 95％可信区间[CI]，1.12-1.46）。对于学校系统或DDSN记录的中度至重度ID的关联更强（HR = 1.84; 95％CI，1.35-2.51）。中期妊娠滴虫病与在公立学校系统中将儿童识别为可训练的弱智或极度弱智的儿童，或正在接受DDSN的ID服务的几率增加了三倍以上。经治疗和未经治疗的滴虫患者的儿童患ID的风险没有显着差异。结论：孕妇滴虫可能是ID的可预防危险因素。

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