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首页> 外文期刊>Annals of epidemiology >Serum organochlorine pesticide residues and risk of gallstone disease: A case-control study in Xiamen
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Serum organochlorine pesticide residues and risk of gallstone disease: A case-control study in Xiamen

机译：血清有机氯农药残留与胆结石风险的关系：厦门市病例对照研究

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Purpose: To investigate the association between serum organochlorine pesticide residues and risk of gallstone disease. Methods: A 1:1, pair-matched, case-control study was designed. Data from 150 patients with gallstones diagnosed by abdominal ultrasonography at a single hospital from June 2009 to June 2010 were collected. A total of 150 patients without gallstones during the same period at the same hospital were recruited as the control group. Capillary gas chromatography was employed to measure the serum concentrations of dichlorodiphenyltrichloroethane (DDT) and hexachlorocyclohexane (HCH) residues. Multiple-factor conditional logistic regression analysis was conducted to estimate the relative risk of gallstones in relation to organochlorine pesticide residues in serum. Results: The percentages of p,p'-DDD and o,p'-DDT in serum of patients were significantly higher than those in serum of controls. The p,p'-DDE, α-HCH, and δ-HCH residues in serum of patients were also significantly increased compared with those in serum of controls. Multiple-factor conditional logistic regression analysis showed that high levels of p,p'-DDE and p,p'-DDT residues were risk factors for gallstone disease. Conclusions: A high level of organochlorine pesticide residues in serum is a potential risk factor for gallstone disease, which suggests that environmental exposure to organochlorine pesticides should be evaluated with respect to gallstone formation.
机译：目的：探讨血清有机氯农药残留与胆结石疾病风险之间的关系。方法：设计了一对1：1配对病例对照研究。收集了2009年6月至2010年6月在一家医院通过腹部超声检查诊断出的150例胆结石患者的数据。入选同一家医院同一时期共150例无胆结石的患者作为对照组。毛细管气相色谱法用于测量二氯二苯基三氯乙烷（DDT）和六氯环己烷（HCH）残留物的血清浓度。进行了多因素条件logistic回归分析，以评估胆结石与血清中有机氯农药残留有关的相对风险。结果：患者血清中p，p'-DDD和o，p'-DDT的百分比显着高于对照组血清。与对照组血清相比，患者血清中的p，p'-DDE，α-HCH和δ-HCH残留也显着增加。多因素条件Logistic回归分析表明，高水平的p，p'-DDE和p，p'-DDT残留是胆结石疾病的危险因素。结论：血清中高水平的有机氯农药残留是造成胆结石疾病的潜在危险因素，这表明应就胆结石的形成对有机氯农药的环境暴露进行评估。

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