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首页> 外文期刊>Annals of epidemiology >psychological distress and premature mortality in the general Population: a prospective study.
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psychological distress and premature mortality in the general Population: a prospective study.

机译：一般人群的心理困扰和过早死亡：一项前瞻性研究。

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PURPOSE: To determine whether higher rates of mortality are observed in people reporting psychological distress, to establish the nature of any excess, and to examine the possible existence of a dose response relationship. METHODS: We conducted a prospective follow-up study of mortality over an eight-year period in the North West of England. A total of 4,501 adults were recruited from two general practices during a population-based survey conducted at the start of 1992. At baseline psychological distress was assessed using the General Health Questionnaire (12-item version, GHQ-12). The relationship between levels of distress and subsequent mortality was examined using Cox proportional hazard models. RESULTS: Risk of all-cause mortality was greatest in subjects reporting the highest levels of distress (hazard ratio (HR) 1.71, 95% CI 1.32-2.23) but was also raised in subjects reporting intermediate distress (HR 1.38 95% CI 1.06-1.79) when compared to those reporting no distress. Increased risk of mortality in subjects reporting distress appeared to be due largely to an excess of deaths from ischaemic heart disease (high distress, HR 1.90, 95% CI 1.08-3.35; intermediate distress, HR 1.58, 95% CI 0.90-2.76) and respiratory diseases (high distress, HR 5.39, 95% CI 2.70-10.78; intermediate distress, HR 2.33, 95% CI 1.12-4.22). CONCLUSIONS: The association between mortality and psychological distress observed in this study seems to arise largely because of premature deaths from ischaemic heart disease and respiratory diseases. The existence of a dose-response effect between distress and mortality provides further evidence to support the existence of a casual relationship.
机译：目的：确定在报告有心理困扰的人中是否观察到更高的死亡率，确定任何过量行为的性质，并检查剂量反应关系的可能存在。方法：我们在英格兰西北部进行了为期八年的死亡率前瞻性随访研究。在1992年初进行的基于人口的调查中，总共从4种成年人中招募了4,501名成年人。在基线时，使用“一般健康状况调查表”（12个项目，GHQ-12）评估了心理困扰。使用Cox比例风险模型检查了痛苦水平与随后死亡率之间的关系。结果：全因死亡的风险在报告最高困扰水平的受试者中最高（危险比（HR）1.71，95％CI 1.32-2.23），但在报告中度困扰的受试者中也有所提高（HR 1.38 95％CI 1.06- 1.79）与没有遇险者相比。报告有困扰的受试者死亡风险增加似乎主要是由于缺血性心脏病导致的死亡人数过多（高困扰，HR 1.90，95％CI 1.08-3.35;中度困扰，HR 1.58，95％CI 0.90-2.76）和呼吸系统疾病（高危，HR 5.39，95％CI 2.70-10.78;中危，HR 2.33，95％CI 1.12-4.22）。结论：本研究中观察到的死亡率与心理困扰之间的联系似乎主要是由于缺血性心脏病和呼吸系统疾病过早死亡所致。困扰和死亡率之间存在剂量反应效应，为进一步证明存在偶然关系提供了进一步的证据。

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