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Efficient organocatalysts derived from simple chiral acyclic amino acids in asymmetric catalysis

机译：在不对称催化中衍生自简单手性无环氨基酸的有效有机催化剂

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摘要

Chiral amino acids have played a key role in the development of organocatalysis from a biomimetic concept to an independent methodology, together with metal catalysis and enzyme catalysis, comprising the three major catalytic methodologies in modern organic synthesis. As an excellent pool for the design of organocatalysts, chiral amino acids have two obvious advantages: ready availability with usually affordable costs and modular structures allowing facile tuning of the catalytic efficiency. Recently, bifunctional/multifunctional primary-secondary amines, tertiary amine-thioureas, aminophosphines easily prepared from simple acyclic amino acids have been developed as efficient organocatalysts for various asymmetric reactions leading to a variety of useful chiral compounds. In this perspective, we present a personal overview of some of these recent advances in this field based on our own research experience.
机译：手性氨基酸在从仿生概念到独立方法的有机催化发展以及金属催化和酶催化的过程中起着关键作用，其中包括现代有机合成中的三种主要催化方法。 作为设计有机催化剂的绝佳池，手性氨基酸具有两个明显的优势：现成的可用性，通常负担得起的成本和模块化结构，可轻松调整催化效率。 最近，双功能/多功能的原发胺，第三级胺 - 硫脲，轻松从简单的无环氨基酸制备的氨基磷是作为各种不对称反应的有效有机催化剂，导致各种有用的手势化合物。 从这个角度来看，我们根据自己的研究经验介绍了该领域的一些最新进展的个人概述。

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