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首页> 外文期刊>Anxiety, stress, and coping >Early life adversity potentiates the effects of later life stress on cumulative physiological dysregulation
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Early life adversity potentiates the effects of later life stress on cumulative physiological dysregulation

机译：早年逆境可增强晚年生活压力对累积生理失调的影响

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Background and Objectives: Previous research indicates that early life adversity may heighten stress reactivity and impair mechanisms for adaptive coping, suggesting that experience of stress in early life may also potentiate adults' physiological vulnerability to stress in later life. The study tested this hypothesis by investigating whether the experience of stressful events and circumstances (SEC) in childhood or adolescence amplified the effect of adulthood SEC on physiological dysregulation (allostatic load, AL) in later midlife. Design: Observational data were used in the present study. Physiological functioning was measured in later midlife (participants' age ranged from 49 to 63 years). Both childhood/adolescence and adulthood SEC were reported retrospectively on the same occasion. Methods: Participants were 5309 Danish men and women from Copenhagen Aging and Midlife Biobank (CAMB). SEC included socioeconomic and family factors. The AL index was based on nine cardiovascular, metabolic, and immune biomarkers. Results: Experience of SEC in both early life and adulthood independently predicted higher AL. In men, experience of SEC in early life also potentiated the effect of SEC in adulthood on AL. Conclusions: The results provide further insight into the mechanisms behind the "biological embedding" of childhood stress.
机译：背景与目的：先前的研究表明，生活中的逆境可能会增强压力反应能力，并削弱适应性应对的机制，这表明，生活在压力中的经历也可能会增强成年人在以后的生活中对压力的生理脆弱性。该研究通过调查童年或青春期的应激事件和情况（SEC）的经验是否放大了成年SEC对中年后期生理失调（上肢负荷）的影响，检验了这一假设。设计：观察数据用于本研究。在中年后期（参与者的年龄范围为49至63岁）测量生理机能。回顾性报道了童年/青春期和成年期SEC。方法：来自哥本哈根老龄化和中年生物库（CAMB）的5309名丹麦男女参加。 SEC包括社会经济和家庭因素。 AL指数基于9种心血管，代谢和免疫生物标志物。结果：SEC在早期和成年期的经历独立地预测了较高的AL。在男性中，SEC在生命早期的经历也增强了SEC在成年期对AL的影响。结论：结果为进一步了解儿童压力“生物嵌入”的机制提供了线索。

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