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首页> 外文期刊>Anthropologischer Anzeiger >Association of ACE (I/D) Polymorphism with MetabolicSyndrome and Hypertension in two Ethnic Groupsin Slovakia
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Association of ACE (I/D) Polymorphism with MetabolicSyndrome and Hypertension in two Ethnic Groupsin Slovakia

机译：ACE（I / D）多态性与斯洛伐克两个族裔代谢综合征和高血压的关系

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The objective of this study was to examine the influence of ACE (I/D) genotypeson recognized risk variables for hypertension and Metabolic Syndrome in two ethnic popula-tion samples from Slovakia. A total of 150 Romany subjects (68 males and 82 females) and167 Slovaks (45 males and 122 females) were examined. They were interviewed during amedical examination and they were investigated with respect to a variety of aspects such asmedical, anthropometrical and life-style. The studied subjects were defined as hypertensiveif the blood pressure was 140/90 mm Hg and Metabolic Syndrome (MS) was definedaccording to criteria of the National Cholesterol Education Program Adult Treatment PanelIII- (NCEP ATPIII). ACE (I/D) polymorphism was subsequently determined by PCR ampli-fication of the ACE gene sequence. In the entire sample, the frequency of the mutant D allelewas higher in the Slovak subjects (D = 0.527) than in the Romany subjects (D = 0.447), butthe difference was not significant (p = 0.053).Neither the Slovak nor the Romany normotensive and hypertensive subjects differed sig-nificantly in the distribution of the three ACE genotypes (Slovak p = 0.169, Romany p =0.116). In both ethnic samples hypertensive men prevailed (Slovak 51.1 % vs. Romany44.1 %). The features of Metabolic Syndrome were identified in both samples; they occurredin 33.3 % of Slovak men and 14.8 % Slovak women vs. 42.9 % of Romany men and 32.4 %Romany women. Regression analysis showed no association between ACE genotypes andhypertension nor between ACE genotypes and MS in these Slovak population samples.
机译：这项研究的目的是在来自斯洛伐克的两个民族人群中检查ACE（I / D）基因型对高血压和代谢综合症风险变量的影响。总共检查了150名罗姆人受试者（68名男性和82名女性）和167名斯洛伐克裔（45名男性和122名女性）。在医学检查期间对他们进行了采访，并就医学，人体测量学和生活方式等各个方面进行了调查。如果根据美国胆固醇教育计划成人治疗小组III-（NCEP ATPIII）的标准定义血压为140/90 mm Hg且代谢综合征（MS），则将研究对象定义为高血压。 ACE（I / D）多态性随后通过ACE基因序列的PCR扩增来确定。在整个样本中，斯洛伐克人（D = 0.527）的突变D等位基因频率高于罗曼人（D = 0.447），但差异不显着（p = 0.053）。血压正常和高血压的受试者在三种ACE基因型的分布上有显着差异（斯洛伐克语p = 0.169，罗曼语p = 0.116）。在这两个族裔样本中，高血压男性均占优势（斯洛伐克为51.1％，罗曼尼为44.1％）。在两个样本中都鉴定出了代谢综合征的特征。在斯洛伐克男性中，这一比例为33.3％，在斯洛伐克女性中为14.8％;而在罗马男性中为42.9％，在罗马女性中为32.4％。回归分析表明，在这些斯洛伐克人群样本中，ACE基因型与高血压之间没有关联，ACE基因型与MS之间也没有关联。

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