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首页> 外文期刊>ANZ journal of surgery >Risk stratification for metastasis from cutaneous squamous ceil carcinoma of the head and neck
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Risk stratification for metastasis from cutaneous squamous ceil carcinoma of the head and neck

机译：头颈部皮肤鳞状细胞癌转移的危险分层

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Background: The purpose of the study was to develop a system of risk stratification, based on clinical and histological factors that would aid prediction of metastasis from cutaneous squamous cell carcinoma (SCC) of the head and neck. Method: The method used was a retrospective case control study comparing clinical and histological parameters of 78 patients who developed metastasis with 92 patients who did not develop metastasis over a 5-year period.Results: The two 'absolute' (highest) risk factors for development of metastatic disease are poor histological differentiation and perineural/lymphovascular infiltration. The three 'relative' risk factors are moderate histological differentiation, diameter >20 mm and Clark level 5.Risk stratification: High-risk lesions have either one of the absolute risk factors or all three of the relative risk factors with a predicted incidence of metastasis of 37%. Intermediate risk lesions have two of three relative risk factors and a predicted incidence of metastasis of 5%. Low-risk lesions have one or none of the relative risk factors and a predicted incidence of meatstasis of 0.3%.Conclusion: Ongoing management of patients with histo-pathologically proven invasive SCC of the head and neck should be based upon risk stratification for metastasis.
机译：背景：本研究的目的是基于临床和组织学因素，开发有助于风险分级的系统，以帮助预测头颈部皮肤鳞状细胞癌（SCC）的转移。方法：所使用的方法是一项回顾性病例对照研究，比较了78名发生转移的患者和92名在5年内未发生转移的患者的临床和组织学参数。结果：两种“绝对”（最高）危险因素转移性疾病的发展是不良的组织学分化和神经周围/淋巴血管浸润。这三个“相对”危险因素是中度组织学分化，直径> 20 mm和克拉克水平5。危险分层：高危险性病变具有绝对危险因素之一或所有三个相对危险因素中有预测的转移发生率占37％。中度危险病变具有三个相对危险因素中的两个，并且预测的转移发生率为5％。低风险病变具有相对危险因素中的一种或一种，并且预测的肉瘤转移率为0.3％。结论：组织病理学证实为头颈部浸润性SCC的患者应根据转移的风险分层进行持续治疗。

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