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首页> 外文期刊>American Journal of Surgical Pathology >Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma.
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Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma.

机译：程序性死亡1在原发性皮肤CD4阳性小/中型多形T细胞淋巴瘤，皮肤假T细胞淋巴瘤和其他类型的皮肤T细胞淋巴瘤中的表达。

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摘要

In this study we investigated whether programmed death-1 (PD-1) could serve as a useful diagnostic marker to differentiate between primary cutaneous CD4 small/medium-sized pleomorphic T-cell lymphoma (PCSM-TCL) and cutaneous pseudo-T-cell lymphomas on the one hand and other types of cutaneous T-cell lymphomas (CTCLs) on the other. Formalin-fixed, paraffin-embedded skin biopsies from 26 patients with PCSM-TCL or pseudo-T-cell lymphoma, including 1 patient with a lymphomatoid drug eruption, and 52 skin biopsies from other types of CTCLs were stained for PD-1. In addition, PD-1-positive cases were stained with antibodies against BCL6, CXCL13, and CD10 to determine a possible relationship with follicular helper T (TFH) cells. In all 26 cases of PCSM-TCL or pseudo-T-cell lymphoma, the medium-sized to large-sized atypical T cells consistently expressed PD-1, BCL6, and CXCL13 but not CD10. PD-1 expression was found in only 2 of 21 cases of mycosis fungoides and in only 2 of 16 cases of cutaneous peripheral T-cell lymphoma, unspecified. All 4 patients with an aggressive epidermotropic cytotoxic CD8 CTCL and all 11 cases with a primary cutaneous CD30 lymphoproliferative disorder were negative for PD-1. In conclusion, PD-1 is typically expressed by atypical cells in PCSM-TCL and pseudo-T-cell lymphoma but is not expressed or is rarely expressed in other types of CTCLs. Therefore, it may serve as a suitable adjunct in differential diagnosis. Our results demonstrate that the atypical cells in PCSM-TCL and pseudo-T-cell lymphomas share a common TFH phenotype and support the view that most cases classified nowadays as PCSM-TCL are identical to cutaneous pseudo-T-cell lymphomas described previously.
机译：在这项研究中，我们调查了程序性死亡1（PD-1）是否可以用作区分原发性皮肤CD4小/中型多形性T细胞淋巴瘤（PCSM-TCL）和皮肤假T细胞的有用的诊断标记一方面是淋巴瘤，另一方面是其他类型的皮肤T细胞淋巴瘤（CTCL）。对26例PCSM-TCL或假T细胞淋巴瘤患者（包括1例淋巴瘤样药疹患者）进行福尔马林固定，石蜡包埋的皮肤活检，并对其他类型CTCL的52例皮肤活检进行了PD-1染色。另外，用抗BCL6，CXCL13和CD10的抗体对PD-1阳性病例进行染色，以确定与卵泡辅助性T（TFH）细胞的可能关系。在所有26例PCSM-TCL或假T细胞淋巴瘤中，中型至大型非典型T细胞始终表达PD-1，BCL6和CXCL13，但不表达CD10。未发现21例真菌病真菌中的2例和16例皮肤周围T细胞淋巴瘤中的2例发现了PD-1表达。所有4例侵袭性表皮细胞毒性CD8 CTCL患者和所有11例原发性皮肤CD30淋巴组织增生性疾病患者均PD-1阴性。总之，PD-1通常由PCSM-TCL和假T细胞淋巴瘤中的非典型细胞表达，但在其他类型的CTCL中不表达或很少表达。因此，它可以作为鉴别诊断的合适辅助手段。我们的研究结果表明PCSM-TCL和假T细胞淋巴瘤中的非典型细胞具有共同的TFH表型，并支持以下观点：当今被归类为PCSM-TCL的大多数病例与前述皮肤假T细胞淋巴瘤相同。

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