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首页> 外文期刊>Apoptosis: An international journal on programmed cell death >Dynamics of lipid raft components during lymphocyte apoptosis: The paradigmatic role of GD3
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Dynamics of lipid raft components during lymphocyte apoptosis: The paradigmatic role of GD3

机译：淋巴细胞凋亡过程中脂质筏成分的动态：GD3的范式作用

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摘要

Several investigations have been carried out since many years in order to precisely address the function of lipid rafts in cell life and death. On the basis of the biochemical nature of lipid rafts, composed by sphingolipids, including gangliosides, sphingomyelin, cholesterol and signaling proteins, a plethora of possible interactions with various subcellular structures has been suggested. Their structural and functional role at the plasma membrane as well as in cell organelles such as endoplasmic reticulum and Golgi apparatus has been analyzed in detail in several studies. In particular, a specific activity of lipid rafts has been hypothesized to contribute to cell death by apoptosis. Although detected in various cell types, the role of lipid rafts in apoptosis has however been mostly studied in lymphocytes where the physiological apoptotic program occurs after CD95/Fas triggering. In this review, the possible contribution of lipid rafts to the cascade of events leading to T cell apoptosis after CD95/Fas ligation are summarized. Particular attention has been given to the mitochondrial raft-like microdomains, which may represent preferential sites where some key reactions can take place and can be catalyzed, leading to either survival or death of T cells.
机译：自从多年以来，已经进行了数项研究，以精确解决脂质筏在细胞生命和死亡中的作用。基于由神经节苷脂，鞘磷脂，胆固醇和信号蛋白等鞘脂组成的脂筏的生化性质，已提出了与各种亚细胞结构的过多相互作用。在一些研究中已经详细分析了它们在质膜以及细胞器如内质网和高尔基体中的结构和功能作用。特别地，已经假设脂质筏的比活性可通过细胞凋亡促进细胞死亡。尽管在各种细胞类型中都检测到了脂质筏在细胞凋亡中的作用，但是在CD95 / Fas触发后发生生理性凋亡程序的淋巴细胞中，却进行了大多数研究。在这篇综述中，总结了脂质筏对CD95 / Fas连接后导致T细胞凋亡的一系列事件的可能贡献。尤其关注线粒体筏状微结构域，其可能代表优先位点，在该位点可能发生某些关键反应并被催化，从而导致T细胞存活或死亡。

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