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首页> 外文期刊>Annals of work exposures and health. >Fungal Fragments and Fungal Aerosol Composition in Sawmills
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Fungal Fragments and Fungal Aerosol Composition in Sawmills

机译：锯木厂中的真菌碎片和真菌气溶胶成分

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Assessment of exposure to fungi has commonly been limited to fungal spore measurements that have shown associations between fungi and development or exacerbation of different airway diseases. Because large numbers of submicronic fragments can be aerosolized from fungal cultures under laboratory conditions, it has been suggested that fungal exposure is more complex and higher than that commonly revealed by spore measurements. However, the assessment of fungal fragments in complex environmental matrix remain limited due to methodological challenges. With a recently developed immunolabeling method for field emission scanning electron microscope (FESEM), we could assess the complex composition of fungal aerosols present in personal thoracic samples collected from two Norwegian sawmills. We found that large fungal fragments (length 1 mu m) dominated the fungal aerosols indicating that the traditional monitoring approach of spores severely underestimate fungal exposure. The composition of fungal aerosols comprised in average 9% submicronic fragments, 62% large fragments, and 29% spores. The average concentrations of large and submicronic fragments (0.2-1 mu m) were 3 x 10(5) and 0.6 x 10(5) particles m(-3), respectively, and correlated weakly with spores (1.4 x 10(5) particles m(-3)). The levels of fragments were 2.6 times higher than the average spore concentration that was close to the proposed hazardous level of 10(5) spores per m(3).The season influenced significantly the fungal aerosol concentrations but not the composition. Furthermore, the ratio of spores in the heterogeneous fungal aerosol composition was significantly higher in saw departments as compared to sorting of green timber departments where the fungal fragments were most prevalent. Being the dominating particles of fungal aerosols in sawmills, fungal fragments should be included in exposure-response studies to elucidate their importance for health impairments. Likewise, the use of fungal aerosol composition in such studies should be considered.
机译：对真菌接触的评估通常仅限于真菌孢子测量结果，这些测量表明真菌与发育与开发或加剧不同气道疾病之间的关联。由于可以在实验室条件下从真菌培养物中燃烧大量的亚微微片段，因此已经提出，真菌暴露比孢子测量值通常更复杂，更高。但是，由于方法论挑战，对复杂环境基质中真菌碎片的评估仍然有限。使用最近开发的用于现场发射扫描电子显微镜（FESEM）的免疫标记方法，我们可以评估从两个挪威锯木厂收集的个人胸腔样品中存在的真菌气溶胶的复杂组成。我们发现，大型真菌碎片（长度＆ 1 mu M）主导了真菌气溶胶，表明孢子的传统监测方法严重低估了真菌的暴露。真菌气溶胶的组成平均包括9％的亚微米片段，62％的大片段和29％的孢子。大和亚微米片段（0.2-1 MU M）的平均浓度分别为3 x 10（5）和0.6 x 10（5）颗粒M（-3），并且与孢子（1.4 x 10（5）颗粒M（-3））。片段的水平比平均孢子浓度高2.6倍，孢子浓度接近所提出的危险水平为每m的10（5）个孢子（3）。季节对真菌气溶胶浓度显着影响，但不影响组成。此外，与真菌碎片最普遍的绿色木材部门相比，锯部门异质真菌气溶胶组成的孢子比显着更高。作为锯木厂中真菌气溶胶的主要颗粒，应将真菌碎片包括在暴露反应研究中，以阐明其对健康障碍的重要性。同样，应考虑在此类研究中使用真菌气溶胶组成。

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