...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Behavioural Brain Research: An International Journal >D1 and D2 dopamine receptor antagonists decrease behavioral bout duration, without altering the bout's repeated behavioral components, in a naturalistic model of repetitive and compulsive behavior
【24h】

D1 and D2 dopamine receptor antagonists decrease behavioral bout duration, without altering the bout's repeated behavioral components, in a naturalistic model of repetitive and compulsive behavior

机译：在重复性和强迫性行为的自然模型中，D1和D2多巴胺受体拮抗剂可减少行为发作持续时间，而不会改变发作的重复行为成分

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nest building behavior in the pregnant female rabbit (Oryctolagus cuniculus) is a model for compulsive behavior in Obsessive Compulsive Disorder (OCD). This behavior comprises a cycle of repeated, stereotyped components (collecting straw, entering nest box and depositing the straw there, returning to collect more straw), which itself is repeated 80+ times in a single bout that lasts approximately 50. min. The bout, in turn, is repeated if necessary, according to the rabbit's perception of whether or not the nest is finished. We administered SCH23390 (5-100μg/kg; D1/D5 antagonist) or raclopride (0.05-1.0. mg/kg; D2/D3 antagonist), subcutaneously to day 28 pregnant female rabbits, 30 or 60. min before placing straw inside their home cage. At doses that minimally affected ambulatory behavior in open field (5-12.5μg/kg SCH23390, 0.5-1.0. mg/kg raclopride), both antagonists dramatically reduced bout duration while not significantly affecting the initiation of straw carrying behavior, the sequential performance of the individual cycle components, maximum cycle frequency, or the total number of bouts performed. These results point to an important role for dopamine neurotransmission for the prolonged expression of a normal, repetitive and compulsive-like behavior. Moreover, the finding that dopamine receptor antagonists decrease the time spent engaged in repetitive behavior (without significantly altering the form of the repetitive behavior itself) suggests a possible explanation for why neuroleptics can be clinically effective for treating OCD.
机译：妊娠雌性兔（穴兔眼）的筑巢行为是强迫症（OCD）的强迫行为模型。此行为包括重复的定型组件（收集稻草，进入巢箱并将稻草存放在那里，然后返回以收集更多稻草）的循环，该循环本身在一次回合中重复80+次，持续约50分钟。然后，根据兔子对巢是否已完成的感觉，如有必要，重复进行该回合。我们将SCH23390（5-100μg/ kg; D1 / D5拮抗剂）或雷氯必利（0.05-1.0。mg / kg; D2 / D3拮抗剂）皮下注射至第28天的雌性母兔，放置30或60分钟，然后再将稻草放入它们的体内。家笼。在开阔地域对门诊行为产生最小影响的剂量（5-12.5μg/ kg SCH23390，0.5-1.0。mg / kg raclopride）下，两种拮抗剂均能显着减少发作持续时间，而不会显着影响稻草携带行为的开始，各个周期的组成部分，最大周期频率或执行的总次数。这些结果表明多巴胺神经传递对于正常，重复和强迫性行为的延长表达具有重要作用。此外，多巴胺受体拮抗剂减少了重复行为所花费的时间（在不显着改变重复行为本身的形式的情况下）的发现，为精神抑制药在临床上可有效治疗强迫症提供了可能的解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号