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首页> 外文期刊>Behavioural pharmacology >Intravenous self-administration of heroin/cocaine combinations (speedball) using nose-poke or lever-press operant responding in mice.
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Intravenous self-administration of heroin/cocaine combinations (speedball) using nose-poke or lever-press operant responding in mice.

机译：在小鼠中使用鼻p或杠杆按下操作者响应静脉注射海洛因/可卡因组合（速球）。

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Acquisition and dose-related self-administration of heroin (H)/cocaine (C) combinations in C57BL/6 x SJL mice were studied in nose-poke or lever-press operant responding procedures. C57BL/6 x SJL mice readily acquired self-administration in both operant procedures with a combination of doses known to be ineffective when each drug was used alone (H: 15 microg/kg and C: 150 microg/kg per injection). Similar numbers of infusions were obtained under conditions of fixed-ratio (FR) 3 versus 1 for the nose-poke and lever-press responses, respectively. Dose-effect curves for heroin:cocaine combinations revealed a pattern corresponding to a leftward shift of the dose-response for intravenous cocaine self-administration. Curves were similar whether generated with 1 or 3 days of availability per dose, or including subjects that did not respond preferentially (> 70% responses) to the hole or lever associated with drug delivery, along with those that did. Motor activity induced by a combination of low doses for each drug was examined (H: 0.375 mg/kg and C: 3.75 mg/kg, i.p.). Under these conditions, the combination of both drugs induced an initial cocaine-like stimulation of horizontal activity, in contrast to the tendency of heroin to decrease activity. It is concluded that heroin:cocaine combinations used in the present study had reinforcing effects in C57BL/6 x SJL mice, and produced a cocaine-like effect in the early part of drug-induced activity sessions, followed by a locomotor profile corresponding to the average of both drugs.
机译：在鼻nose或杠杆按压操作反应程序中研究了C57BL / 6 x SJL小鼠中海洛因（H）/可卡因（C）组合的获得和剂量相关的自我给药。 C57BL / 6 x SJL小鼠很容易在两种操作程序中获得自我给药，并且已知每种药物单独使用时无效的剂量组合（每次注射H：15 microg / kg和C：150 microg / kg）。在固定比率（FR）3对1的鼻刺和杠杆按压反应条件下，分别获得了相似的输注次数。海洛因：可卡因组合的剂量效应曲线显示了一种模式，该模式对应于静脉注射可卡因自我给药的剂量反应向左移动。无论是每剂量1天或3天的可用性生成的曲线，还是包括对那些与药物输送相关的孔或杠杆没有优先响应（> 70％响应）的受试者，以及产生响应的受试者，曲线都是相似的。检查了由每种药物的低剂量组合引起的运动活动（H：0.375 mg / kg和C：3.75 mg / kg，腹膜内）。在这些条件下，与海洛因降低活性的趋势相反，两种药物的组合均诱导了类似可卡因的初始水平活性刺激。结论是，本研究中使用的海洛因：可卡因组合在C57BL / 6 x SJL小鼠中具有增强作用，并在药物诱导的活性过程的早期产生可卡因样作用，随后出现与两种药物的平均值。

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