...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Science Immunology >Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity
【24h】

Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity

机译：分馏CoVID-19 AD5载体疫苗可改善病毒特异性免疫力

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SARS-CoV-2 has caused a global pandemic that has infected more than 250 million people worldwide. Although several vaccine candidates have received emergency use authorization, there is still limited knowledge on how vaccine dosing affects immune responses. We performed mechanistic studies in mice to understand how the priming dose of an adenovirus-based SARS-CoV-2 vaccine affects long-term immunity to SARS-CoV-2. We first primed C57BL/6 mice with an adenovirus serotype 5 vaccine encoding the SARS-CoV-2 spike protein, similar to that used in the CanSino and Sputnik V vaccines. The vaccine prime was administered at either a standard dose or 1000-fold lower dose, followed by a boost with the standard dose 4 weeks later. Initially, the low dose prime induced lower immune responses relative to the standard dose prime. However, the low dose prime elicited immune responses that were qualitatively superior and, upon boosting, exhibited substantially more potent recall and functional capacity. We also report similar effects with a simian immunodeficiency virus (SIV) vaccine. These findings show an unexpected advantage of fractionating vaccine prime doses, warranting a reevaluation of vaccine trial protocols for SARS-CoV-2 and other pathogens.
机译：SARS-COV-2引起了全球大流行，全球感染了超过2.5亿人。尽管几名候选疫苗已获得紧急使用授权，但关于疫苗剂量如何影响免疫反应的知识仍然有限。我们在小鼠中进行了机械研究，以了解基于腺病毒的SARS-COV-2疫苗的启动剂量如何影响对SARS-COV-2的长期免疫力。我们首先用腺病毒血清型5疫苗编码SARS-COV-2尖峰蛋白的C57BL/6小鼠，类似于Cansino和Sputnik V疫苗中使用的疫苗。以标准剂量或1000倍的剂量给予疫苗素数，然后在4周后加强标准剂量。最初，低剂量素诱导的相对于标准剂量素的较低的免疫反应。然而，低剂量的素数引起的免疫反应在质量上优越，并且在提升后表现出更大的召回和功能能力。我们还报告了猿猴免疫缺陷病毒（SIV）疫苗的类似作用。这些发现表明了分馏疫苗量剂量的意外优势，因此需要重新评估SARS-COV-2和其他病原体的疫苗试验方案。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号