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首页> 外文期刊>Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology >Effects of cigarette smoking on hearing recovery from noise-induced temporary hearing threshold shifts in mice.
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Effects of cigarette smoking on hearing recovery from noise-induced temporary hearing threshold shifts in mice.

机译：吸烟对噪声引起的小鼠临时听力阈值转移的听力恢复的影响。

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摘要

HYPOTHESIS: Cigarette smoking may potentiate noise-induced hearing loss. BACKGROUND: Many epidemiological studies have shown that cigarette smoking is a major risk factor for noise-induced hearing loss. METHODS: BALB/c mice were exposed to passive smoking for 2 h/d for 2 weeks before exposure to 110-dB sound pressure level white noise for 3 hours once. Hearing was assessed via the auditory brainstem response with tone-burst stimulation and distortion product otoacoustic emissions before and at 1, 3, 5, 7, 14, 21, and 28 days after noise exposure. Oxidative stress and hypoxia were assessed by immunostaining with 8-oxoG and hypoxia-inducible factor 1alpha, respectively. RESULTS: Control mice unexposed to both smoking and noise and mice exposed to smoking only showed no shift in hearing threshold. In contrast, mice exposed to noise only or smoking plus noise showed abrupt increases in hearing threshold. In mice exposed to noise only, hearing threshold returned to prenoise levels after 2 weeks. However, in mice exposed to smoking plus noise, the loss of hearing was significantly higher, and hearing threshold did not return to the pre-exposure levels until 4 weeks later. Positive staining with 8-oxoG and hypoxia-inducible factor 1alpha were observed in the inner ear of the smoking-only and smoking-plus-noise group similar to noise-only mice, whereas no positive staining was observed in control group. CONCLUSION: These results indicate that cigarette smoking may potentiate the harmful effects of noise on hearing and disturb the recovery mechanism in the cochlea.
机译：假设：吸烟可能会增强噪声引起的听力损失。背景：许多流行病学研究表明，吸烟是噪声引起的听力损失的主要危险因素。方法：BALB/C小鼠暴露于被动吸烟2小时2周，然后暴露于110 dB的声压水平白噪声3小时。通过听觉脑干反应评估听力，并在噪声暴露后1、3、5、7、14、21和28天之前和1、3、5、7、14、21和28天进行刺激和失真产物。分别用8-oxog和低氧诱导因子1阿尔帕进行免疫染色来评估氧化应激和缺氧。结果：对照吸烟和噪声的对照小鼠，暴露于吸烟的小鼠只显示出听力阈值的变化。相反，仅暴露于噪声或吸烟加噪声的小鼠在听力阈值中突然增加。在仅暴露于噪声的小鼠中，听力阈值2周后恢复到核水平。但是，在暴露于吸烟加噪声的小鼠中，听力的丧失明显更高，直到4周后，听力阈值才恢复到暴露前的水平。在仅吸烟的内耳和吸烟 - 噪声组的内耳中观察到用8-oxog和低氧诱导因子1阿尔帕染色的阳性染色，类似于仅噪声小鼠，而在对照组中未观察到阳性染色。结论：这些结果表明，吸烟可能会增强噪声对听力的有害影响，并干扰耳蜗中的恢复机制。

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