...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Antiviral Research >Levocetirizine inhibits rhinovirus-induced ICAM-1 and cytokine expression and viral replication in airway epithelial cells.
【24h】

Levocetirizine inhibits rhinovirus-induced ICAM-1 and cytokine expression and viral replication in airway epithelial cells.

机译：左西替利嗪抑制鼻病毒诱导的ICAM-1和细胞因子的表达以及在气道上皮细胞中的病毒复制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Levocetirizine inhibits the production of intercellular adhesion molecule (ICAM)-1 and secretion of interleukin (IL)-6 and IL-8, which may have beneficial effects on the pathophysiologic changes related to human rhinovirus (HRV) infection. We investigated the effects of levocetirizine on rhinovirus infection in primary human nasal epithelial cells (HNEC) and A549 cells. Cells were treated with different concentrations of levocetirizine, ranging from 0.5, 5 or 50nM, either starting at the time of infection and continuing thereafter, or beginning 24h before infection and continuing thereafter. Levocetirizine treatment inhibited the HRV-induced increase in ICAM-1 mRNA and protein levels, as well as the HRV-induced expression of IL-6 and IL-8 mRNA and protein levels. Viral titer, as measured by culture in MRC-5 cells, was reduced by levocetirizine. Levocetirizine treatment also reduced the increased nuclear factor-kappa B (NF-kappaB) expression seen with HRV infection. Levocetirizine inhibited the expression of Toll-like receptor (TLR)3 mRNA and protein levels. These findings indicate that, in HNEC and A549 cells, levocetirizine inhibits HRV replication and HRV-induced upregulation of ICAM-1, IL-6, and IL-8, TLR3 expression and NF-kappaB activation. The results of this study suggest that levocetirizine may have a possible clinical application in the treatment of airway inflammation caused by HRV infection.
机译：左西替利嗪抑制细胞间粘附分子（ICAM）-1的产生以及白介素（IL）-6和IL-8的分泌，这可能对与人类鼻病毒（HRV）感染有关的病理生理变化产生有益影响。我们调查了左西替利嗪对鼻病毒感染原代人鼻上皮细胞（HNEC）和A549细胞的影响。用不同浓度的左西替利嗪处理细胞，浓度范围为0.5nM，5nM或50nM，从感染时开始并随后继续，或在感染前24h开始并随后继续。左西替利嗪治疗抑制了HRV诱导的ICAM-1 mRNA和蛋白水平的升高，以及HRV诱导的IL-6和IL-8 mRNA和蛋白水平的表达。左西替利嗪降低了MRC-5细胞中培养的病毒滴度。左西替利嗪治疗还降低了HRV感染时核因子-κB（NF-kappaB）表达的增加。左西替利嗪抑制Toll样受体（TLR）3 mRNA和蛋白水平的表达。这些发现表明，在HNEC和A549细胞中，左西替利嗪抑制HRV复制以及HRV诱导的ICAM-1，IL-6和IL-8，TLR3表达和NF-κB激活的上调。这项研究的结果表明，左西替利嗪在治疗HRV感染引起的气道炎症中可能具有临床应用价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号