Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.

He G; Qiao J; Dong C; He C; Zhao L; Tian Y

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Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.

机译：中国北方分离出的H5N1禽流感病毒中的金刚烷胺耐药性。

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We tested the amantadine-resistance among avian influenza A (H5N1) viruses isolated from chicken in Hebei Province of Northern China from 2001 to 2005, and investigated the amantadine use in this area. Plague reduction assay in MDCK cells showed that 83.3% isolates (5/6) were amantadine-resistant strains. The M2 sequence analysis revealed that four of five resistant isolates contained the point mutations (Ser to Asn) at position 31 that could confer resistance to amantadine. These results indicated that the incidence of amantadine-resistant viruses isolated in Northern China was particularly high. In the investigation of amantadine use, we found that amantadine was used extensively in poultry farms in this area, which maybe was one of reasons of the high amantadine-resistance incidence.

机译：我们测试了2001年至2005年从中国北方河北省鸡中分离出的禽流感A（H5N1）病毒对金刚烷胺的抗性，并调查了该地区金刚烷胺的使用情况。 MDCK细胞中的鼠疫减少检测结果表明，有83.3％的分离株（5/6）是耐金刚烷胺的菌株。 M2序列分析表明，五个抗性分离株中有四个在第31位含有点突变（Ser到Asn），可赋予对金刚烷胺的抗性。这些结果表明，在中国北方分离的耐金刚烷胺的病毒的发病率特别高。在对金刚烷胺使用的调查中，我们发现金刚烷胺在该地区的家禽养殖场中被广泛使用，这可能是金刚烷胺抗药性高的原因之一。

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《Antiviral Research》 |2008年第1期|共5页
作者
He G; Qiao J; Dong C; He C; Zhao L; Tian Y;
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正文语种 eng
中图分类药学;
关键词
Amantadine; Cancer resistance to treatment; Viral; China; Influenza; 金刚烷胺; 中国; 流感;

机译：Amantadine;Cancer resistance to treatment;Viral;China;Influenza;金刚烷胺;中国;流感;

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专利

1. Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China. [J] . He G, Qiao J, Dong C, Antiviral Research . 2008,第1期

机译：中国北方分离出的H5N1禽流感病毒中的金刚烷胺耐药性。
2. Characterization of highly pathogenic H5N1 avian influenza viruses isolated from poultry markets in central China. [J] . Chen J, Fang F, Yang Z Virus Research: An International Journal of Molecular and Cellular Virology . 2009,第1a2期

机译：从中国中部家禽市场分离的高致病性H5N1禽流感病毒的特征。
3. Antigenic, genetic, and pathogenic characterization of H5N1 highly pathogenic avian influenza viruses isolated from dead whooper swans (Cygnus cygnus) found in northern Japan in 2008. [J] . Okamatsu M, Tanaka T, Yamamoto N, Virus Genes . 2010,第3期

机译：H5N1高致病性禽流感病毒的抗原，遗传和致病性特征，它们是从2008年在日本北部发现的死天鹅（天鹅）中分离出来的。
4. Genetic and antigenic characterization of avian influenza A (H5N1) viruses isolated from humans in mainland China [C] . Yuelong Shu, Yu Lan, Leying Wen, Symposium on Novel and Re-emerging Respiratory Viral Diseases . 2008

机译：禽流感A（H5N1）病毒的遗传与抗原性表征于中国大陆人类分离的病毒
5. Molecular basis for adaptation of avian h5N1 influenza viruses in mammals [D] . Kim, Jin Hyun 2010

机译：禽h5N1流感病毒在哺乳动物中适应的分子基础
6. Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans between 2003 and 2008 in northern Vietnam [O] . Quynh Mai Le, Mutsumi Ito, Yukiko Muramoto, -1

机译：越南北部2003年至2008年间从人类分离出的高致病性禽类H5N1甲型流感病毒的致病性
7. Molecular characterization of highly pathogenic H5N1 avian influenza A viruses isolated from raccoon dogs in China. [O] . Xian Qi, Xihan Li, Paul Rider, 2009

机译：从中国浣熊中分离的高致病性H5N1禽流感a病毒的分子特征。

Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China.

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