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首页> 外文期刊>Antiviral Research >Foot-and-mouth disease virus causes a decrease in spleen dendritic cells and the early release of IFN-α in the plasma of mice. Differences between infectious and inactivated virus
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Foot-and-mouth disease virus causes a decrease in spleen dendritic cells and the early release of IFN-α in the plasma of mice. Differences between infectious and inactivated virus

机译：口蹄疫病毒引起小鼠脾脏树突状细胞减少和IFN-α的早期释放。传染性和灭活病毒之间的区别

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摘要

Foot-and-mouth disease (FMD) is a highly contagious and acute viral disease of cloven-hoofed animals. From an economical point of view, it is the most important disease of livestock worldwide. It is known that the virus interacts with dendritic cells, both in the natural host and in mice, but the impact of this interaction on the adaptive immune response is controversial. Currently available vaccines are based on inactivated forms of the FMD virus. Little is known about the differences between infectious and inactivated virus, in terms of dendritic cell subsets involved in immune response activation. The present work, which was carried out in the murine model, shows that live virus infection induces a reduction in splenic dendritic cell subsets. In addition, lymphocyte proliferation is inhibited in the early stages of infection associated with IFN-α induction, but is restored to normal values 5. days post-infection when pro-inflammatory cytokines was produced. In contrast, the inactivated virus increases the percentage of plasmacytoid dendritic cells in the spleen and the production of IL-10, which triggers the activation of a T regulatory response.
机译：口蹄疫（FMD）是偶蹄类动物的高度传染性和急性病毒性疾病。从经济角度来看，它是全世界最重要的牲畜疾病。已知该病毒在天然宿主和小鼠中均与树突状细胞相互作用，但是这种相互作用对适应性免疫应答的影响是有争议的。当前可用的疫苗基于FMD病毒的灭活形式。就涉及免疫应答激活的树突状细胞亚群而言，关于感染性病毒和灭活病毒之间的差异知之甚少。在鼠模型中进行的当前工作表明，活病毒感染可诱导脾脏树突状细胞亚群的减少。另外，在与IFN-α诱导相关的感染的早期，淋巴细胞增殖被抑制，但是在感染后5天当产生促炎细胞因子时恢复到正常值。相反，灭活的病毒会增加脾脏中浆细胞样树突状细胞的百分比和IL-10的产生，从而触发T调节反应的激活。

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