• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Antiviral chemistry & chemotherapy >Herpes simplex virus helicase-primase inhibitors: recent findings from the study of drug resistance mutations.
【24h】

Herpes simplex virus helicase-primase inhibitors: recent findings from the study of drug resistance mutations.

机译：单纯疱疹病毒解旋酶-引发酶抑制剂：耐药性突变研究的最新发现。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

After several decades during which nucleoside analogues (especially acyclovir and penciclovir and their prodrugs) have benefited many patients suffering from herpes simplex virus (HSV) infections, the discovery of the helicase-primase inhibitors (HPIs) represents an interesting new approach. Although antiviral resistance has not been a major problem for nucleoside analogues in immunocompetent patients, the problem of acyclovir resistance in immunocompromised patients is well documented. Several HPIs are extremely potent antiviral compounds and may, therefore, offer an important alternative therapy in these patients. The potential for synergy, not just for the inhibition of virus replication but also to delay the appearance of drug-resistant virus, needs to be thoroughly investigated. The study of resistance to HPIs has been important towards understanding the mechanism of action of these compounds and confirming the target function. However, during the course of our studies on HPI resistance, we have made a number of interesting observations that may be relevant to their clinical use. This article draws attention to the major observations on HPI resistance reported by others and to our own recently published observations that have extended this expanding area of antiviral research.
机译：几十年来，核苷类似物（特别是阿昔洛韦和喷昔洛韦及其前药）使许多患有单纯疱疹病毒（HSV）感染的患者受益，之后，解旋酶-引发酶抑制剂（HPI）的发现代表了一种有趣的新方法。尽管抗病毒耐药性不是免疫活性患者中核苷类似物的主要问题，但免疫受损患者中无环鸟苷耐药性的问题已得到充分证明。几种HPI是非常有效的抗病毒化合物，因此可能为这些患者提供重要的替代疗法。协同作用的潜力，不仅是抑制病毒复制，而且是延迟耐药病毒的出现，都需要彻底研究。对HPIs的抗性研究对于理解这些化合物的作用机理和确定目标功能具有重要意义。但是，在我们对HPI耐药性的研究过程中，我们做了许多有趣的观察，可能与它们的临床用途有关。本文提请注意其他人报告的有关HPI抗药性的主要观察结果，以及我们自己最近发表的观察结果，这些观察结果扩展了抗病毒研究的这一不断扩展的领域。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号