• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vegetos: an international journal of plant research >Gum acacia-PVA hydrogel blends for wound healing
【24h】

Gum acacia-PVA hydrogel blends for wound healing

机译：口香糖acacia-PVA混合水凝胶对伤口愈合

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hydroactive wound dressings ensure a physiologically moist wound milieu which enhances healing and patient comfort. Polymers like polyurethane, salts of alginic acid, collagen, cellulose and other gelable polysaccharides are commonly used for preparation of hydrogels but have their own limitations. In the present study acacia gum, a natural polysaccharide having known antioxidant and wound healing properties has been blended with polyvinyl alcohol and prepared hydrogel matrix further explored for itswound healing potential. Structural characterization of blended films by FTIR and XRD method showed that polysaccharide gum associated with PVA molecules via acetal bridges and they were amorphous in nature. The gel exhibited free swell capacity of 64 g0.100 cm~(-2), which is comparable to the commercially available films recommended for heavily exuding wounds. The GA/PVA blends showed 34% moisture retention (Rh) ability after 24 h and their fluid absorbing (26%) and fluid donation (16%) ability makethem suitable for moist and fibrinous wounds. They also exhibited blood compatibility, oxygen permeability, bacterial impermeability, antioxidant activity, iron chelation ability and biodeg-radability. In vivo healing potential has been evaluated on Swiss albino mice where hydrogel coated wounds showed faster and scar-less wound regeneration. In vitro Povidone-Iodine loading and release studies showed that iodine release followed Fickian diffusion process. Prepared hydrogels are breathable and hydrophilic in nature and are able to maintain appropriate moisture level at wound surface, suitable for acceleration of wound healing process. Based upon the studied properties the designed hydrogels are recommended for dry, necrotic and low exuding wounds.
机译：Hydroactive伤口敷料确保生理湿润伤口环境增强了治疗和病人舒适。聚氨酯、海藻酸盐、胶原蛋白、纤维素和其他能变成胶状的多糖通常用于制备水凝胶有自己的局限性。阿拉伯树胶,一种天然多糖抗氧化剂和伤口愈合性能混合了聚乙烯醇及准备水凝胶为itswound矩阵进一步探讨治疗的潜力。通过红外光谱和x射线衍射方法表明,混合电影多糖胶与PVA分子有关通过缩醛桥梁和他们非晶态大自然。64 g0.100厘米~(2),这是可比的商业化电影推荐严重着伤口。34%水分潴留(Rh) 24 h后的能力和他们的液体吸收(26%)和液体makethem适合捐赠(16%)能力潮湿和纤维蛋白的伤口。血液相容性,氧气渗透,细菌不渗透性、抗氧化活性、铁螯合能力和biodeg-radability。体内一直在评估治疗的潜力瑞士白化小鼠在水凝胶涂伤口显示速度更快,scar-less伤口再生。体外聚乙烯吡咯酮碘加载和释放研究表明,碘释放之后Fickian扩散过程。透气、亲水在自然和有能力保持适当的湿度在伤口表面,适合加速伤口愈合过程。属性水凝胶设计建议干、坏死和低着伤口。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号