Transcription factor-mediated reprogramming toward hematopoietic stem cells

Ebina Wataru; Rossi Derrick J.

首页> 外文期刊>EMBO Journal >Transcription factor-mediated reprogramming toward hematopoietic stem cells

【24h】

Transcription factor-mediated reprogramming toward hematopoietic stem cells

机译：转录factor-mediated重组对造血干细胞

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

De novo generation of human hematopoietic stem cells (HSCs) from renewable cell types has been a long sought-after but elusive goal in regenerative medicine. Paralleling efforts to guide pluripotent stem cell differentiation by manipulating developmental cues, substantial progress has been made recently toward HSC generation via combinatorial transcription factor (TF)-mediated fate conversion, a paradigm established by Yamanaka's induction of pluripotency in somatic cells by mere four TFs. This review will integrate the recently reported strategies to directly convert a variety of starting cell types toward HSCs in the context of hematopoietic transcriptional regulation and discuss how these findings could be further developed toward the ultimate generation of therapeutic human HSCs.

机译：新创一代人类造血干细胞细胞(hsc)一直是来自可再生的细胞类型久的但难以捉摸的目标再生医学。指导多能干细胞分化操纵发展线索,可观对HSC最近进展通过组合转录因子生成(TF)介导的命运转换,一个范式建立了山中感应的多能性的体细胞仅仅四个助教。本文将整合最近报道直接把各种各样的策略开始向肝星状细胞的细胞类型造血转录调控和进一步讨论如何将这些发现发展的终极一代人类肝星状细胞治疗。

著录项

来源
《EMBO Journal》 |2015年第6期|694-709|共16页
作者
Ebina Wataru; Rossi Derrick J.;
展开▼
作者单位

Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Hematopoietic Stem Cells; Transcription Factors; Stem Cell DifferentiationCell fatereprogrammingpluripotencyDiploid Cell;

机译：造血干细胞;转录因素;干细胞DifferentiationCellfatereprogrammingpluripotencyDiploid细胞;

相似文献

外文文献
中文文献
专利

1. Rapid identification of the origin of hematopoietic cells after allogeneic hematopoietic stem cell transplantation for leukemia with DNA-fingerprinting [J] . 钱新华, 邢献志, 朱为国, 中国人民解放军军医大学学报：英文版 . 1997,第001期
2. Reprogramming of mouse neural stem cells to induced pluripotent stem cells using Oct4 combined with microRNA [J] . Qiuyue Yan, Jie Xu, Yanqiang Zhan, 中国神经再生研究：英文版 . 2011,第001期
3. Reprogramming of mouse neural stem cells to induced pluripotent stem cells using Oct4 combined with microRNA [J] . Qiuyue Yan, Jie Xu, Yanqiang Zhan, 中国神经再生研究（英文版） . 2011,第001期
4. Erratum: Turning reactive glia into functional neurons in the brain (Cell Stem Cell (2014) 14 (133-134)) [J] . LuJ., BradleyR.A., ZhangS.-C. Cell stem cell . 2014,第5期

机译：勘误：将反应性胶质细胞转变为大脑中的功能神经元（Cell Stem Cell（2014）14（133-134））
5. Erratum: In vivo activation of a conserved microRNA program induces mammalian heart regeneration (Cell Stem Cell (2014) 15 (589-604)) [J] . AguirreA., MontserratN., ZacchignaS., Cell stem cell . 2014,第6期

机译：勘误：体内保守的microRNA程序的激活诱导哺乳动物心脏再生（Cell Stem Cell（2014）15（589-604））
6. Erratum: Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog (Cell Stem Cell (2013) 12 426-439)) [J] . SirkoS., BehrendtG., JohanssonP.A., Cell stem cell . 2013,第5期

机译：勘误：受伤的大脑中的反应性神经胶质细胞获得了对声波刺猬的反应的干细胞特性（Cell Stem Cell（2013）12 426-439）
7. Advances in STEM-CELL. A Free Software for TEM and STEM Analysis and Simulations: Probe Deconvolution in STEM-HAADF [C] . V.Grillo International Metallographic Society Annual meeting;Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting . 2011

机译：STEM-CELL的进展。用于TEM和STEM分析和仿真的免费软件：STEM-HAADF中的探针反卷积
8. Inhibition of liver and bone marrow derived dendritic cell maturation and function by interleukin-6 activation of Signal Transducer and Activator of Transcription-3 [D] . Lunz, John George, III 2007

机译：IL-6激活信号转导子和Transcription-3激活子抑制肝脏和骨髓来源的树突状细胞成熟和功能
9. Novel Technique for Inducing Neural Crest Fate in Embryonic Stem Cells (Stem Cells 2009;27:2896-2905) [O] . Jung Hwan Oh, Gunjan Tiwari 2011

机译：在胚胎干细胞中诱导神经C命运的新技术（Stem Cells 2009; 27：2896-2905）
10. Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: A matched-pair analysis [O] . Ishiyama, Ken, Takami, Akiyoshi, Kanda, Yoshinobu, 2012

机译：allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: a matched-pair analysis
11. Strengthening the STEM Education & Workforce Pipeline: Insights from the BHEF U.S. STEM Education Model Led to the STEM Higher Education and Workforce Project [R] . 2011

机译：加强sTEm教育和劳动力管道：BHEF美国sTEm教育模式对sTEm高等教育和劳动力项目的启示

Transcription factor-mediated reprogramming toward hematopoietic stem cells

摘要

著录项

相似文献

相关主题

期刊订阅