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首页> 外文期刊>Animal biology >Fasting and postprandial conditions affect both fatty acids and lipid compositions in the hypothalamus and fat-soluble vitamins in the serum of male rats
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Fasting and postprandial conditions affect both fatty acids and lipid compositions in the hypothalamus and fat-soluble vitamins in the serum of male rats

机译：空腹和餐后状况会影响雄性大鼠下丘脑的脂肪酸和脂质成分以及血清中的脂溶性维生素

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The purpose of this study was to examine the effects of fasting and re-feeding on lipid derivative patterns in the hypothalamus, and on vitamin, cholesterol and malondialdehyde (MDA) levels in serum. Adult male Wistar albino rats were assigned (n = 6/group) as follows: normally-fed controls (CON), fasted for 24 h (24F), fasted for 48 h (48F), and fed normally for 2 d after fasting for 48 h (FAF). Biochemical measures were analyzed by gas chromatography (GC) and high performance liquid chromatography (HPLC). Our results demonstrate that hypothalamic saturated fatty acid (C16:0, C18:0) levels were lower, and unsaturated fatty acid (C22:6 n-3, C22:4 n-6, C20:4 n-6) levels were higher, in the 48F and FAF groups than in CON (P <0.01). In addition, hypothalamic monounsaturated fatty acid (MUFA) levels were lower, and polyunsaturated fatty acids (PUFA) levels were higher, in 24F than in CON. Total hypothalamic lipids in both 24F and 48F were higher than CON, and cholesterol was elevated in the hypothalami of all experimental groups as compared to CON. Serum malondialdehyde was higher in fasted and FAF groups; 24F and 48F also had higher serum cholesterol levels, than CON (P <0.01,P <0.001). Serum α-tocoferol, retinol and vitamin C values were lower in 48F than CON (P <0.05). In conclusion, we demonstrate that feeding state can significantly alter brain fatty acid and lipid derivative levels, and serum concentrations of cholesterol and vitamins. These changes may consequently influence lipid peroxidation, fatty acid synthase or desaturase system in hypothalamic fields.
机译：这项研究的目的是检查禁食和重新喂食对下丘脑脂质衍生物模式以及血清中维生素，胆固醇和丙二醛（MDA）水平的影响。如下分配成年雄性Wistar白化病大鼠（n = 6 /组）：正常进食对照（CON），禁食24 h（24F），禁食48 h（48F），以及禁食后正常喂食2 d。 48小时（FAF）。通过气相色谱（GC）和高效液相色谱（HPLC）分析生化指标。我们的结果表明，下丘脑饱和脂肪酸（C16：0，C18：0）含量较低，而不饱和脂肪酸（C22：6 n-3，C22：4 n-6，C20：4 n-6）含量较高，在48F和FAF组中比在CON中（P <0.01）。此外，在24F中，下丘脑单不饱和脂肪酸（MUFA）的水平较低，而多不饱和脂肪酸（PUFA）的水平高于CON。与CON相比，所有实验组的下丘脑中24F和48F的总下丘脑脂质均高于CON，而胆固醇升高。空腹组和FAF组血清丙二醛水平较高。 24F和48F的血清胆固醇水平也高于CON（P <0.01，P <0.001）。 48F的血清α-生育酚，视黄醇和维生素C值均低于CON（P <0.05）。总之，我们证明了进食状态可以显着改变大脑脂肪酸和脂质衍生物的水平，以及血清胆固醇和维生素的浓度。这些变化可能因此影响下丘脑区域的脂质过氧化，脂肪酸合酶或去饱和酶系统。

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