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首页> 外文期刊>Animal biology >Changes in the hepatic and renal structure and function after a growth promoter boldenone injection in rabbits
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Changes in the hepatic and renal structure and function after a growth promoter boldenone injection in rabbits

机译：生长促进剂马来烯酮注射后兔肝，肾结构和功能的变化

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Boldenone is an androgenic steroid that improves the growth and food conversion in food producing animals. In most countries worldwide, this anabolic steroid is forbidden for meat production. Recently, it is used by bodybuilders in both off-season and pre-contest, where it is well known for increasing vascularity while preparing for a bodybuilding contest. Therefore, our study was designed to investigate the possible effect of using growth promoter boldenone undecylenate on the rabbit liver and kidney structure and functions. Thirty-two adult New Zealand rabbits were divided into four groups. Control group includes animals that injected intramuscularly with olive oil and dissected after 3 weeks. Three experimental groups include animals that receive one, two and three intramuscular injections of 5 mg/kg body weight boldenone, respectively and dissected after 3, 6 and 9 weeks respectively, where the interval of each dose of boldenone was three weeks. Intramuscular injection of rabbits with boldenone increased the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), urea and creatinine compared with the control group.We also found significant increases in the total protein, total lipid, nitric oxide (NO), superoxide dismutase activity (SOD), glutathione (GSH) and malondialdehyde (MDA) in liver and kidney tissues compared with the control group. Intramuscular injection of rabbits with boldenone exhibited mild to severe histopathological lesions in liver tissue as hepatocellular vacuolation in the centrilobular region and sinusoids and in the kidney, the renal glomerulei had completely lost their typical shape with the appearance of some vacuoles of different shapes and sizes with markedly congested sinusoidal and dilated blood vessels. These findings suggest that misuse of growth promoter boldenone undecylenate may contribute to continuous damage of the hepatic and renal function and structure that may lead to a progressive hepatic and renal diseases, so people should be careful if they want to use such steroids to enhance their strength and endurance.
机译：鲍登酮是一种雄激素类固醇，可改善食品生产动物的生长和食物转化。在全球大多数国家/地区，这种合成代谢类固醇都禁止用于肉类生产。最近，健美运动员在休赛期和比赛前都使用它，众所周知，在准备健美比赛时，它会增加血管含量。因此，我们的研究旨在调查使用生长促进剂十一烯十一烷酸十一烯酮对家兔肝肾结构和功能的可能作用。将三十二只成年新西兰兔分成四组。对照组包括肌肉注射橄榄油并在3周后解剖的动物。三个实验组包括分别接受1、2和3次肌肉注射5mg / kg体重的双烯酮的动物，并分别在3、6和9周后解剖，其中每剂双烯酮的间隔为三周。肌肉注射苯丁二酮对家兔的血清谷氨酸草酰乙酸转氨酶（SGOT），血清谷氨酸丙酮酸转氨酶（SGPT），尿素和肌酐较对照组增加，总蛋白，总脂质，一氧化氮（NO ），肝脏和肾脏组织中的超氧化物歧化酶活性（SOD），谷胱甘肽（GSH）和丙二醛（MDA）与对照组相比。肌内注射苯丁二酮的兔子在肝组织中表现出轻度至严重的组织病理学损害，因为在小叶区域和窦内肝细胞空泡化，在肾脏中，肾小球完全失去了典型的形状，出现了一些不同形状和大小的液泡。正弦和扩张血管明显充血。这些发现表明滥用生长促进剂十一烯十一烷酮可能会持续破坏肝和肾功能及结构，从而可能导致进行性肝肾疾病，因此，如果要使用此类类固醇来增强体力，人们应格外小心和耐力。

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